Contrasting genomic diversity in two closely related postharvest pathogens: penicillium digitatum and penicillium expansum

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• dc.contributor.author Julca, Ireneca
• dc.contributor.author Droby, Samirca
• dc.contributor.author Sela, Noaca
• dc.contributor.author Marcet Houben, Marinaca
• dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-ca
• dc.date.accessioned 2016-06-03T17:11:10Z
• dc.date.available 2016-06-03T17:11:10Z
• dc.date.issued 2015
• dc.description.abstract Penicillium digitatum and Penicillium expansum are two closely related fungal plant pathogens causing green and blue mold in harvested fruit, respectively. The two species differ in their host specificity, being P. digitatum restricted to citrus fruits and P. expansum able to infect a wide range of fruits after harvest. Although host-specific Penicillium species have been found to have a smaller gene content, it is so far unclear whether these different host specificities impact genome variation at the intraspecific level. Here we assessed genome variation across four P. digitatum and seven P. expansum isolates from geographically distant regions. Our results show very high similarity (average 0.06 SNPs [single nucleotide polymorphism] per kb) between globally distributed isolates of P. digitatum pointing to a recent expansion of a single lineage. This low level of genetic variation found in our samples contrasts with the higher genetic variability observed in the similarly distributed P. expansum isolates (2.44 SNPs per kb). Patterns of polymorphism in P. expansum indicate that recombination exists between genetically diverged strains. Consistent with the existence of sexual recombination and heterothallism, which was unknown for this species, we identified the two alternative mating types in different P. expansum isolates. Patterns of polymorphism in P. digitatum indicate a recent clonal population expansion of a single lineage that has reached worldwide distribution. We suggest that the contrasting patterns of genomic variation between the two species reflect underlying differences in population dynamics related with host specificities and related agricultural practices. It should be noted, however, that this results should be confirmed with a larger sampling of strains, as new strains may broaden the diversity so far found in P. digitatum.ca
• dc.description.sponsorship This work was supported in part by Grants from the Spanish Ministry of Economy and Competitiveness: “Centro de Excelencia Severo Ochoa 2013–2017” SEV-2012-0208, and BIO2012-37161 cofounded by European Regional Development Fund (ERDF); from the European Union and ERC Seventh Framework Programme (FP7/2007-2013) under grant agreement ERC-2012-StG-310325, and grant from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No H2020-MSCA-ITN-2014-642095; and Peruvian Ministry of Education: “Beca Presidente de la República” (2013-III).
• dc.format.mimetype application/pdfca
• dc.identifier.citation Julca I, Droby S, Sela N, Marcet-Houben M, Gabaldón T. Contrasting genomic diversity in two closely related postharvest pathogens: penicillium digitatum and penicillium expansum. Genome biology and evolution. 2015; 8(1): 218-227. DOI 10.1093/gbe/evv252ca
• dc.identifier.doi http://dx.doi.org/10.1093/gbe/evv252
• dc.identifier.issn 1471-2164
• dc.identifier.uri http://hdl.handle.net/10230/26825
• dc.language.iso engca
• dc.publisher Oxford University Pressca
• dc.relation.ispartof Genome biology and evolution. 2015; 8(1): 218-227
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310325
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642095
• dc.rights © The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/ca
• dc.subject.keyword Penicillium
• dc.subject.keyword Genome variation
• dc.subject.keyword Genomics
• dc.subject.other Fongs patògensca
• dc.title Contrasting genomic diversity in two closely related postharvest pathogens: penicillium digitatum and penicillium expansumca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca