Comparing two targeted biopsy schemes for detecting clinically significant prostate cancer in magnetic resonance index lesions: Two- to four-core versus saturated transperineal targeted biopsy
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- dc.contributor.author Morote, Juan
- dc.contributor.author Paesano, Nahuel
- dc.contributor.author Picola, Natàlia
- dc.contributor.author Miró, Berta
- dc.contributor.author Abascal-Junquera, José María
- dc.contributor.author Servian, Pol
- dc.contributor.author Trilla, Enrique
- dc.contributor.author Méndez, Olga
- dc.date.accessioned 2025-03-11T07:13:31Z
- dc.date.available 2025-03-11T07:13:31Z
- dc.date.issued 2024
- dc.description.abstract Since the optimal scheme for targeted biopsies of magnetic resonance imaging (MRI) suspicious lesions remains unclear, we compare the efficacy of two schemes for these index lesions. A prospective trial was conducted in 1161 men with Prostate Imaging Reporting and Data System v 2.1 3-5 undergoing targeted and 12-core systematic biopsy in four centers between 2021 and 2023. Two- to four-core MRI-transrectal ultrasound fusion-targeted biopsies via the transperineal route were conducted in 900 men in three centers, while a mapping per 0.5 mm core method (saturated scheme) was employed in 261 men biopsied in another center. A propensity-matched 261 paired cases were selected for avoiding confounders other than the targeted biopsy scheme. CsPCa (grade group ≥ 2) was identified in 125 index lesions (41.1%) when the two- to four-core scheme was employed, while in 187 (71.9%) when the saturated biopsy (p < 0.001) was used. Insignificant PCa (iPCa) was detected in 18 and 11.1%, respectively (p = 0.019). Rates of csPCa and iPCa remained similar in systematic biopsies. CsPCa detected only in systematic biopsies were 5 and 1.5%, respectively (p = 0.035) in each group. The saturated scheme for targeted biopsies detected more csPCa and less iPCa than did the two- to four-core scheme in the index lesions. The rate of csPCa detected only in the systematic biopsies decreased when the saturated scheme was employed.
- dc.format.mimetype application/pdf
- dc.identifier.citation Morote J, Paesano N, Picola N, Miró B, Abascal JM, Servian P, Trilla E, et al. Comparing two targeted biopsy schemes for detecting clinically significant prostate cancer in magnetic resonance index lesions: Two- to four-core versus saturated transperineal targeted biopsy. Cancers (Basel). 2024 Jun 23;16(13):2306. DOI: 10.3390/cancers16132306
- dc.identifier.doi http://dx.doi.org/10.3390/cancers16132306
- dc.identifier.issn 2072-6694
- dc.identifier.uri http://hdl.handle.net/10230/69904
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Cancers (Basel). 2024 Jun 23;16(13):2306
- dc.rights © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Index lesion
- dc.subject.keyword Number of cores
- dc.subject.keyword Prostate cancer
- dc.subject.keyword Targeted biopsy
- dc.title Comparing two targeted biopsy schemes for detecting clinically significant prostate cancer in magnetic resonance index lesions: Two- to four-core versus saturated transperineal targeted biopsy
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion