Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
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- dc.contributor.author García de Herreros, Antonio
- dc.contributor.author Duñach, Mireia
- dc.date.accessioned 2019-11-25T08:30:49Z
- dc.date.available 2019-11-25T08:30:49Z
- dc.date.issued 2019
- dc.description.abstract In contrast to non-canonical ligands, canonical Wnts promote the stabilization of β-catenin, which is a prerequisite for formation of the TCF4/β-catenin transcriptional complex and activation of its target genes. This pathway is initiated by binding of Wnt ligands to the Frizzled/LRP5/6 receptor complex, and it increases the half-life of β-catenin by precluding the phosphorylation of β-catenin by GSK3 and its binding to the βTrCP1 ubiquitin ligase. Other intercellular signals are also activated by Wnt ligands that do not inhibit GSK3 and increase β-catenin protein but that either facilitate β-catenin transcriptional activity or stimulate other transcriptional factors that cooperate with it. In this review, we describe the layers of complexity of these signals and discuss their crosstalk with β-catenin in activation of transcriptional targets.
- dc.description.sponsorship This research was funded by grants from the Ministerio de Ciencia, Innovación y Universidades (RTI2018-099719-B-100 cofunded by Fondos Feder, SAF2013-40922-R1 and SAF2016-76461-R). Support from ICREA Academia is also appreciated.
- dc.format.mimetype application/pdf
- dc.identifier.citation García de Herreros A, Duñach M. Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization. Cells. 2019 Sep 25;8(10):1148. DOI: 10.3390/cells8101148
- dc.identifier.doi http://dx.doi.org/10.3390/cells8101148
- dc.identifier.issn 2073-4409
- dc.identifier.uri http://hdl.handle.net/10230/42948
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Cells. 2019 Sep 25;8(10):1148
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2013-40922-R1
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2016-76461-R
- dc.rights © García de Herreros A, Duñach M. by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Frizzled
- dc.subject.keyword LRP5/6
- dc.subject.keyword ROR2
- dc.subject.keyword STAT3
- dc.subject.keyword Wnt signaling
- dc.subject.keyword YAP/TAZ
- dc.subject.keyword β-catenin
- dc.title Intracellular signals activated by canonical wnt ligands independent of GSK3 inhibition and β-catenin stabilization
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion