Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)

Mostra el registre complet Registre parcial de l'ítem

• dc.contributor.author Navarro Mateu, Fernando
• dc.contributor.author Quesada, Mari Paz
• dc.contributor.author Escámez, Teresa
• dc.contributor.author Alcaraz, María José
• dc.contributor.author Seiquer de la Peña, Catherine
• dc.contributor.author Salmerón, Diego
• dc.contributor.author Huerta, José María
• dc.contributor.author Vilagut Saiz, Gemma, 1975-
• dc.contributor.author Chirlaque, María Dolores
• dc.contributor.author Navarro, Carmen
• dc.contributor.author Husky, Mathilde M.
• dc.contributor.author Kessler, Ronald C.
• dc.contributor.author Alonso Caballero, Jordi
• dc.contributor.author Martínez, Salvador
• dc.date.accessioned 2019-10-03T10:37:46Z
• dc.date.available 2019-10-03T10:37:46Z
• dc.date.issued 2019
• dc.description.abstract Objective To explore the separate and joint associations of childhood adversities and 5-HTTLPR polymorphism as risk factors for substance use disorders among adults. Design Retrospective case-control study. Setting Cases from the substance unit and controls from a representative sample of the adult general population in the metropolitan area of Murcia (Spain). Participants Cases were defined as outpatients 18 years old or older currently in the treatment for alcohol, opioids or cocaine use disorders in the clinical unit. Controls were randomly selected among individuals without substance use disorders who participated in the Psychiatric Enquiry to General Population in Southeast Spain-Murcia (PEGASUS-Murcia) project, a cross-sectional study of a representative sample of the adult general population. In all, 142 cases and 531 controls were interviewed and a subsample of 114 cases (80.3%) and 329 controls (62%) provided a biological sample. Exposure A history of 12 childhood adversities, lifetime mental disorders and sociodemographic variables was assessed with the Composite International Diagnostic Interview (CIDI)version 3.0). Buccal swabs were obtained to genotype the 5-HTTLPR polymorphism with the biallelic and the triallelic classification. Main outcome and measure Multivariable logistic regression models were performed to estimate adjusted ORs and 95% CI. Results Childhood adversities were associated with an elevated risk of substance use disorders (OR=5.77, 95% CI 3.46 to 9.61). Homozygotes for the short allele of the 5-HTTLPR polymorphism also showed the elevated risk of substance use disorders for the biallelic and triallelic classification: (1.97 (1.10 to 3.55) and 2.01 (1.11 to 3.64), respectively). No evidence for gene × environment interactions was found. Conclusions Childhood adversities and the 5-HTTLPR polymorphism are involved in the aetiology of substance use disorders though findings exploring the existence of a gene–environment interaction were inconclusive.
• dc.format.mimetype application/pdf
• dc.identifier.citation Navarro-Mateu F, Quesada MP, Escámez T, Alcaráz MJ, Seiquer de la Peña C, Salmerón D, Huerta JM, Vilagut G, Chirlaque MD, Navarro C, Husky M, Kessler RC, Alonso J, Martínez S. Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain). BMJ Open. 2019; 9(9):e030328. DOI 10.1136/bmjopen-2019-030328
• dc.identifier.doi http://dx.doi.org/10.1136/bmjopen-2019-030328
• dc.identifier.issn 2044-6055
• dc.identifier.uri http://hdl.handle.net/10230/42379
• dc.language.iso eng
• dc.publisher BMJ Publishing Group
• dc.relation.ispartof BMJ Open. 2019; 9(9):e030328
• dc.rights © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Case-control study
• dc.subject.keyword Childhood adversities 5-HTTLPR polymorphism
• dc.subject.keyword Risk factors
• dc.subject.keyword Substance use disorders
• dc.title Childhood adversities and 5-HTTLPR polymorphism as risk factors of substance use disorders: retrospective case-control study in Murcia (Spain)
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion