Chronic sleep fragmentation mimicking sleep apnea does not worsen left-ventricular function in healthy and heart failure mice

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  • dc.contributor.author Cabrera-Aguilera, Ignacio
  • dc.contributor.author Benito Villabriga, Begoña
  • dc.contributor.author Tajes Orduña, Marta
  • dc.contributor.author Farré, Ramon
  • dc.contributor.author Gozal, David
  • dc.contributor.author Almendros, Isaac
  • dc.contributor.author Farré López, Núria
  • dc.date.accessioned 2020-06-03T06:28:16Z
  • dc.date.available 2020-06-03T06:28:16Z
  • dc.date.issued 2020
  • dc.description.abstract Aims: Obstructive sleep apnea (OSA) has been associated with heart failure (HF). Sleep fragmentation (SF), one of the main hallmarks of OSA, induces systemic inflammation, oxidative stress and sympathetic activation, hence potentially participating in OSA-induced cardiovascular consequences. However, whether SF per se is deleterious to heart function is unknown. The aim of this study was to non-invasively evaluate the effect of SF mimicking OSA on heart function in healthy mice and in mice with HF. Methods and Results: Forty C57BL/6J male mice were randomized into 4 groups: control sleep (C), sleep fragmentation (SF), isoproterenol-induced heart failure (HF), and mice subjected to both SF+HF. Echocardiography was performed at baseline and after 30 days to evaluate left ventricular end-diastolic (LVEDD) and end-systolic (LVESD) diameters, left ventricular ejection fraction (LVEF) and fraction shortening (FS). The effects of SF and HF on these parameters were assessed by two-way ANOVA. Mice with isoproterenol-induced HF had significant increases in LVEDD and LVESD, as well as a decreases in LVEF and FS (p = 0.013, p = 0.006, p = 0.027, and p = 0.047, respectively). However, no significant effects emerged with SF (p = 0.480, p = 0.542, p = 0.188, and p = 0.289, respectively). Conclusion: Chronic SF mimicking OSA did not induce echocardiographic changes in cardiac structure and function in both healthy and HF mice. Thus, the deleterious cardiac consequences of OSA are likely induced by other perturbations associated with this prevalent condition, or result from interactions with underlying comorbidities in OSA patients.
  • dc.description.sponsorship Funding. This work was supported in part by the Spanish Ministry of Economy and Competitiveness (SAF2017-85574-R). IC-A was supported by CONICYT PFCHA—Chilean Doctorate Fellowship 2017; Grant No. 72180089. DG was supported in part by National Institutes of Health grants HL130984 and HL140548.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Cabrera-Aguilera I, Benito B, Tajes M, Farré R, Gozal D, Almendros I, et al. Chronic sleep fragmentation mimicking sleep apnea does not worsen left-ventricular function in healthy and heart failure mice. Front Neurol. 2020 Jan 9; 10:1364. DOI: 10.3389/fneur.2019.01364
  • dc.identifier.doi http://dx.doi.org/10.3389/fneur.2019.01364
  • dc.identifier.issn 1664-2295
  • dc.identifier.uri http://hdl.handle.net/10230/44885
  • dc.language.iso eng
  • dc.publisher Frontiers
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/SAF2017-85574-R
  • dc.rights Copyright © 2020 Cabrera-Aguilera, Benito, Tajes, Farré, Gozal, Almendros and Farré. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). https://creativecommons.org/licenses/by/4.0/. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri https://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Heart failure
  • dc.subject.keyword Sleep apnea
  • dc.subject.keyword Sleep breathing disorders
  • dc.subject.keyword Sleep fragmentation
  • dc.subject.keyword Ventricular function
  • dc.title Chronic sleep fragmentation mimicking sleep apnea does not worsen left-ventricular function in healthy and heart failure mice
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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