Mid- and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: A randomized, clinical trial

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• dc.contributor.author Hernando Redondo, Javier
• dc.contributor.author Toloba, Andrea
• dc.contributor.author Benaiges Foix, David
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Martínez-González, Miguel Ángel, 1957-
• dc.contributor.author Corella, Dolores
• dc.contributor.author Estruch, Ramón
• dc.contributor.author Tinahones Madueño, Francisco José
• dc.contributor.author Ros, Emilio
• dc.contributor.author Goday Arno, Alberto
• dc.contributor.author Castañer, Olga
• dc.contributor.author Fitó Colomer, Montserrat
• dc.date.accessioned 2023-04-04T06:02:35Z
• dc.date.available 2023-04-04T06:02:35Z
• dc.date.issued 2022
• dc.description.abstract Background: Obesity is produced by the enlargement of the adipose tissue. Functioning as an endocrine organ, it releases and receives information through a complex network of cytokines, hormones, and substrates contributing to a low-chronic inflammation environment. Diet and healthy habits play key roles in the prevention of obesity and its related pathologies. In this regard, there is a need to switch to healthier and more appetizing diets, such as the Mediterranean one. Objective: To compare the mid-and long-term effects of two Mediterranean diet (MedDiet) interventions, one energy-reduced plus physical activity promotion versus a non-restrictive diet, on peripheral satiety-related hormones, weight loss, glucose/lipid metabolism, and pro-inflammatory markers in subjects with obesity/overweight and metabolic syndrome. Materials and methods: A randomized, lifestyle intervention was conducted in 23 Spanish centers, with a large cohort of patients presenting metabolic syndrome. Our study is a subproject set in IMIM (Hospital del Mar Research Institute). Participants were men and women, aged 55-75 and 60-75, respectively, who at baseline met at least three metabolic syndrome components. Subjects were assigned to two intervention groups: (1) an intensive lifestyle intervention with an energy-reduced MedDiet and physical activity promotion (intervention group) with the aim of weight loss; and (2) a normocaloric MedDiet (control). We quantified in a subsample of 300 volunteers from Hospital del Mar Research Institute (Barcelona), following analytes at baseline, 6 months, and 1 year: glucose, HbA1c, triglycerides, total cholesterol, high-density lipoprotein cholesterol, LDL cholesterol, C-peptide, ghrelin, GLP-1, glucagon, insulin, leptin, PAI-1, resistin, and visfatin. Anthropometric and classical cardiovascular risk factors were also determined. A multivariate statistical model was employed to compare the two groups. Linear mixed-effect models were performed to compare changes in risk factors and biomarkers between intervention groups and over time. Results: Compared to participants in the control group, those in intervention one showed greater improvements in weight, waist circumference, insulin (P < 0.001), glucose metabolism-related compounds (P < 0.05), triglyceride-related lipid profile (P < 0.05), leptin, blood pressure, and pro-inflammatory markers such as PAI-1 (P < 0.001) at mid-and/or long-term. High-sensitivity C-reactive protein, resistin, and vifastin also decreased in both groups. Conclusion: A weight loss intervention employing a hypocaloric MedDiet and physical activity promotion has beneficial effects on adiposity, glucose metabolism, lipid profile, leptin, and pro-inflammatory markers, such as PAI-1 in both mid-and long-term.
• dc.format.mimetype application/pdf
• dc.identifier.citation Hernando-Redondo J, Toloba A, Benaiges D, Salas-Salvadó J, Martínez-Gonzalez MA, Corella D, Estruch R, Tinahones FJ, Ros E, Goday A, Castañer O, Fitó M. Mid- and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: A randomized, clinical trial. Front Nutr. 2022 Nov 18;9:950900. DOI: 10.3389/fnut.2022.950900
• dc.identifier.doi http://dx.doi.org/10.3389/fnut.2022.950900
• dc.identifier.issn 2296-861X
• dc.identifier.uri http://hdl.handle.net/10230/56406
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Front Nutr. 2022 Nov 18;9:950900
• dc.rights © 2022 Hernando-Redondo, Toloba, Benaiges, Salas-Salvadó, Martínez-Gonzalez, Corella, Estruch, Tinahones, Ros, Goday, Castañer and Fitó. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Mediterranean diet (MedDiet)
• dc.subject.keyword PAI-1
• dc.subject.keyword Inflammation
• dc.subject.keyword Leptin
• dc.subject.keyword Metabolic syndrome
• dc.title Mid- and long-term changes in satiety-related hormones, lipid and glucose metabolism, and inflammation after a Mediterranean diet intervention with the goal of losing weight: A randomized, clinical trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion