Risk of breast cancer two years after a benign biopsy depends on the mammographic feature prompting recall

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• dc.contributor.author Vernet-Tomás, Maria
• dc.contributor.author Louro, Javier
• dc.contributor.author Román, Marta
• dc.contributor.author Saladié, Francina
• dc.contributor.author Posso, Margarita
• dc.contributor.author Prieto, Miguel
• dc.contributor.author Vázquez, Ivonne
• dc.contributor.author Baré, Marisa
• dc.contributor.author Peñalva, Lupe
• dc.contributor.author Vidal, Carmen
• dc.contributor.author Bargalló Castelló, Xavier
• dc.contributor.author Sánchez, Mar
• dc.contributor.author Ferrer, Joana
• dc.contributor.author Espinàs, Josep Alfons
• dc.contributor.author Quintana, María Jesús
• dc.contributor.author Rodríguez Arana, Ana Maria
• dc.contributor.author Castells, Xavier
• dc.contributor.author BELE Study Group
• dc.date.accessioned 2021-09-28T06:19:20Z
• dc.date.issued 2021
• dc.description.abstract Objective: We aimed to explore whether the type of mammographic feature prompting a false-positive recall (FPR) during mammography screening influences the risk and timing of breast cancer diagnosis, particularly if assessed with invasive procedures. Study design: We included information on women screened and recalled for further assessment in Spain between 1994 and 2015, with follow-up until 2017, categorizing FPRs by the assessment (noninvasive or invasive) and mammographic feature prompting the recall. Main outcome measures: Breast cancer rates in the first two years after FPR (first period) and after two years (second period). Results: The study included 99,825 women with FPRs. In both periods, the breast cancer rate was higher in the invasive assessment group than in the noninvasive group (first period 12 ‰ vs 1.9 ‰, p < 0.001; second period 4.4‰ vs 3.1‰, p < 0.001). During the first period, the invasive assessment group showed diverse breast cancer rates for each type of mammographic feature, with a higher rate for asymmetric density (31.9‰). When the second period was compared with the first, the breast cancer rate decreased in the invasive assessment group (from 12‰ to 4.4‰, p < 0.001) and increased in the noninvasive assessment group (from 1.9‰ to 3.1‰, p < 0.001). Conclusion: In the context of mammography screening, the risk of breast cancer diagnosis during the first two years after FPR was particularly high for women undergoing invasive assessment; importantly, the risk was modified by type of mammographic feature prompting the recall. This information could help to individualize follow-up after exclusion of malignancy.
• dc.format.mimetype application/pdf
• dc.identifier.citation Vernet-Tomás M, Louro J, Román M, Saladié F, Posso M, Prieto M, Vázquez I, Baré M, Peñalva L, Vidal C, Bargalló X, Sánchez M, Ferrer J, A Espinàs J, Quintana MJ, Rodríguez-Arana A, Castells X; BELE study group. Risk of breast cancer two years after a benign biopsy depends on the mammographic feature prompting recall. Maturitas. 2021;144:53-9. DOI: 10.1016/j.maturitas.2020.10.024
• dc.identifier.doi http://dx.doi.org/10.1016/j.maturitas.2020.10.024
• dc.identifier.issn 0378-5122
• dc.identifier.uri http://hdl.handle.net/10230/48512
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Maturitas. 2021;144:53-9
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.maturitas.2020.10.024
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Breast cancer screening
• dc.subject.keyword Breast cancer risk
• dc.subject.keyword False-positive recall
• dc.subject.keyword Invasive assessment
• dc.subject.keyword Mammographic feature
• dc.title Risk of breast cancer two years after a benign biopsy depends on the mammographic feature prompting recall
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion