Specific nuclear magnetic resonance lipoprotein subclass profiles and central arterial stiffness in type 1 Diabetes Mellitus: a Case control study

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• dc.contributor.author Llauradó Cabot, Gemma
• dc.contributor.author Amigó, Núria
• dc.contributor.author Albert; Ballesta, Silvia
• dc.contributor.author Albert, Lara
• dc.contributor.author Mazarico, Isabel
• dc.contributor.author Fernández Veledo, Sonia
• dc.contributor.author Pedro-Botet, Juan Carlos
• dc.contributor.author Vendrell, Joan
• dc.contributor.author González Clemente, José Miguel
• dc.date.accessioned 2021-03-05T07:44:17Z
• dc.date.available 2021-03-05T07:44:17Z
• dc.date.issued 2019
• dc.description.abstract Background: Dyslipidemia has been associated with vascular complications of type 1 diabetes mellitus (T1DM). We examined the proton nuclear magnetic resonance (NMR)-assessed lipoprotein subclass profiles in subjects with T1DM compared with those of healthy subjects and assessed the potential relationship of these profiles with arterial stiffness. Methods: Eighty-four participants with T1DM of at least 10 years duration and no clinical cardiovascular disease (age: 35-65 years; 50% men) and 42 healthy participants were evaluated for: (1) clinical and anthropometric data (including classical cardiovascular risk factors), (2) insulin sensitivity by estimated glucose disposal rate, (3) microvascular complications, (4) NMR-assessed lipoprotein subclass profile, and (5) arterial stiffness (aortic pulse wave velocity). Results: Participants with T1DM had an apparently better conventional lipid profile than healthy participants, but with significant differences in NMR-assessed lipoprotein profiles such as higher triglyceride content of low-density lipoprotein (LDL) and high-density lipoprotein (HDL). In healthy participants, arterial stiffness was associated with NMR-based LDL subclasses. By contrast, in T1DM participants, arterial stiffness was independently associated mainly with NMR-based very-low-density lipoprotein (VLDL) subclasses: positively with total VLDL particles (and subclasses) and VLDL triglyceride content, and negatively with LDL and HDL particle sizes. These results were maintained after adjustments for classical cardiovascular risk factors. Conclusions: Subjects with T1DM, while having an apparently better conventional lipid profile than healthy controls, presented significant alterations in their NMR-assessed lipoprotein profile. The association between arterial stiffness and NMR-assessed lipoprotein profiles also differed in both groups. These results support a potential role of the identified differences in the residual cardiovascular risk in T1DM.
• dc.format.mimetype application/pdf
• dc.identifier.citation Llauradó G, Amigó N, Cano A, Ballesta S, Albert L, Mazarico I, et al. Specific nuclear magnetic resonance lipoprotein subclass profiles and central arterial stiffness in type 1 Diabetes Mellitus: a Case control study. J Clin Med. 2019 Nov 5; 8(11): 1875. DOI: 10.3390/jcm8111875
• dc.identifier.doi http://dx.doi.org/10.3390/jcm8111875
• dc.identifier.issn 2077-0383
• dc.identifier.uri http://hdl.handle.net/10230/46669
• dc.language.iso eng
• dc.publisher MDPI
• dc.rights Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Arterial stiffness
• dc.subject.keyword Cardiovascular risk
• dc.subject.keyword Lipoprotein subclass profiles
• dc.subject.keyword Nuclear magnetic resonance spectroscopy
• dc.subject.keyword Preclinical atherosclerosis
• dc.subject.keyword Type 1 diabetes mellitus
• dc.title Specific nuclear magnetic resonance lipoprotein subclass profiles and central arterial stiffness in type 1 Diabetes Mellitus: a Case control study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion