Long non-coding RNA-polycomb intimate rendezvous

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  • dc.contributor.author Cerase, Andrea
  • dc.contributor.author Tartaglia, Gian Gaetano
  • dc.date.accessioned 2020-11-10T07:05:59Z
  • dc.date.available 2020-11-10T07:05:59Z
  • dc.date.issued 2020
  • dc.description.abstract The interaction between polycomb-repressive complexes 1/2 (PRC1/2) and long non-coding RNA (lncRNA), such as the X inactive specific transcript Xist and the HOX transcript antisense RNA (HOTAIR), has been the subject of intense debate. While cross-linking, immuno-precipitation and super-resolution microscopy argue against direct interaction of Polycomb with some lncRNAs, there is increasing evidence supporting the ability of both PRC1 and PRC2 to functionally associate with RNA. Recent data indicate that these interactions are in most cases spurious, but nonetheless crucial for a number of cellular activities. In this review, we suggest that while PRC1/2 recruitment by HOTAIR might be direct, in the case of Xist, it might occur indirectly and, at least in part, through the process of liquid-liquid phase separation. We present recent models of lncRNA-mediated PRC1/2 recruitment to their targets and describe potential RNA-mediated roles in the three-dimensional organization of the nucleus.
  • dc.description.sponsorship A.C. had been funded by a Rett Syndrome Research Trust (RSRT) and a BARTS Charity grants and by QMUL intramural support. The research leading to these results has been supported by European Research Council (RIBOMYLOME 309545 and ASTRA 855923), the Spanish Ministry of Economy and Competitiveness (BFU2017-86970-P) and H2020 projects (IASIS 727658 and INFORE 825080).
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Cerase A, Tartaglia GG. Long non-coding RNA-polycomb intimate rendezvous. Open Biol. 2020; 10(9):200126. DOI: 10.1098/rsob.200126
  • dc.identifier.doi http://dx.doi.org/10.1098/rsob.200126
  • dc.identifier.issn 2046-2441
  • dc.identifier.uri http://hdl.handle.net/10230/45698
  • dc.language.iso eng
  • dc.publisher Royal Society
  • dc.relation.ispartof Open Biol. 2020; 10(9):200126
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/309545
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/855923
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86970-P
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/727658
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/825070
  • dc.rights © 2020 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword HOTAIR RNA
  • dc.subject.keyword RNA secondary structure
  • dc.subject.keyword RNA-protein interaction
  • dc.subject.keyword Xist RNA
  • dc.subject.keyword Long non-coding RNAs (lncRNA)
  • dc.subject.keyword Phase separation
  • dc.subject.keyword Polycomb-repressive complexes 1/2 (PRC1/2)
  • dc.title Long non-coding RNA-polycomb intimate rendezvous
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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