Comparison of Rotterdam and Barcelona magnetic resonance imaging risk calculators for predicting clinically significant prostate cancer

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  • dc.contributor.author Morote, Juan
  • dc.contributor.author Borque-Fernando, Ángel
  • dc.contributor.author Triquell, Marina
  • dc.contributor.author Campistol, Miriam
  • dc.contributor.author Servian, Pol
  • dc.contributor.author Abascal-Junquera, José María
  • dc.contributor.author Planas, Jacques
  • dc.contributor.author Méndez, Olga
  • dc.contributor.author Esteban, Luis M.
  • dc.contributor.author Trilla, Enrique
  • dc.date.accessioned 2023-09-18T06:24:26Z
  • dc.date.available 2023-09-18T06:24:26Z
  • dc.date.issued 2023
  • dc.description.abstract Background: Magnetic resonance imaging (MRI)-based risk calculators (MRI-RCs) individualise the likelihood of clinically significant prostate cancer (csPCa) and improve candidate selection for prostate biopsy beyond the Prostate Imaging Reporting and Data System (PI-RADS). Objective: To compare the Barcelona (BCN) and Rotterdam (ROT) MRI-RCs in an entire population and according to the PI-RADS categories. Design setting and participants: A prospective comparison of BCN- and ROT-RC in 946 men with suspected prostate cancer in whom systematic biopsy was performed, as well as target biopsies of PI-RADS ≥3 lesions. Outcome measurements and statistical analysis: Saved biopsies and undetected csPCa (grade group ≥2) were determined. Results and limitations: The csPCa detection was 40.8%. The median risks of csPCa from BCN- and ROT-RC were, respectively, 67.1% and 25% in men with csPCa, whereas 10.5% and 3% in those without csPCa (p < 0.001). The areas under the curve were 0.856 and 0.844, respectively (p = 0.116). BCN-RC showed a higher net benefit and clinical utility over ROT-RC. Using appropriate thresholds, respectively, 75% and 80% of biopsies were needed to identify 50% of csPCa detected in men with PI-RADS <3, whereas 35% and 21% of biopsies were saved, missing 10% of csPCa detected in men with PI-RADS 3. BCN-RC saved 15% of biopsies, missing 2% of csPCa in men with PI-RADS 4, whereas ROT-RC saved 10%, missing 6%. No RC saved biopsies without missing csPCa in men with PI-RADS 5. Conclusions: ROT-RC provided a lower and narrower range of csPCa probabilities than BCN-RC. BCN-RC showed a net benefit over ROT-RC in the entire population. However, BCN-RC was useful in men with PI-RADS 3 and 4, whereas ROT-RC was useful only in those with PI-RADS 3. No RC seemed to be helpful in men with negative MRI and PI-RADS 5. Patient summary: Barcelona risk calculator was more helpful than Rotterdam risk calculator to select candidates for prostate biopsy.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Morote J, Borque-Fernando Á, Triquell M, Campistol M, Servian P, Abascal JM, Planas J, Méndez O, Esteban LM, Trilla E. Comparison of Rotterdam and Barcelona magnetic resonance imaging risk calculators for predicting clinically significant prostate cancer. Eur Urol Open Sci. 2023;53:46-54. DOI: 10.1016/j.euros.2023.03.013
  • dc.identifier.doi http://dx.doi.org/10.1016/j.euros.2023.03.013
  • dc.identifier.issn 2666-1691
  • dc.identifier.uri http://hdl.handle.net/10230/57899
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Eur Urol Open Sci. 2023;53:46-54
  • dc.rights © 2023 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Clinically significant
  • dc.subject.keyword Early detection
  • dc.subject.keyword Magnetic resonance imaging
  • dc.subject.keyword Predictive model
  • dc.subject.keyword Prostate cancer
  • dc.subject.keyword Risk calculator
  • dc.title Comparison of Rotterdam and Barcelona magnetic resonance imaging risk calculators for predicting clinically significant prostate cancer
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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Articles (Hospital del Mar Research Institute)
Articles (Departament de Medicina i Ciències de la Vida)