Harmonization of brain PET images in multi-center PET studies using Hoffman phantom scan

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  • dc.contributor.author Shekari, Mahnaz
  • dc.contributor.author Verwer, Eline E.
  • dc.contributor.author Yaqub, Maqsood
  • dc.contributor.author Daamen, Marcel
  • dc.contributor.author Buckley, Christopher, 1948-
  • dc.contributor.author Frisoni, Giovanni B.
  • dc.contributor.author Visser, Pieter Jelle
  • dc.contributor.author Farrar, Gill
  • dc.contributor.author Barkhof, Frederik
  • dc.contributor.author Gispert López, Juan Domingo
  • dc.contributor.author Boellaard, Ronald
  • dc.contributor.author AMYPAD Consortium
  • dc.date.accessioned 2024-05-07T06:58:36Z
  • dc.date.available 2024-05-07T06:58:36Z
  • dc.date.issued 2023
  • dc.description.abstract Background: Image harmonization has been proposed to minimize heterogeneity in brain PET scans acquired in multi-center studies. However, standard validated methods and software tools are lacking. Here, we assessed the performance of a framework for the harmonization of brain PET scans in a multi-center European clinical trial. Method: Hoffman 3D brain phantoms were acquired in 28 PET systems and reconstructed using site-specific settings. Full Width at Half Maximum (FWHM) of the Effective Image Resolution (EIR) and harmonization kernels were estimated for each scan. The target EIR was selected as the coarsest EIR in the imaging network. Using "Hoffman 3D brain Analysis tool," indicators of image quality were calculated before and after the harmonization: The Coefficient of Variance (COV%), Gray Matter Recovery Coefficient (GMRC), Contrast, Cold-Spot RC, and left-to-right GMRC ratio. A COV% ≤ 15% and Contrast ≥ 2.2 were set as acceptance criteria. The procedure was repeated to achieve a 6-mm target EIR in a subset of scans. The method's robustness against typical dose-calibrator-based errors was assessed. Results: The EIR across systems ranged from 3.3 to 8.1 mm, and an EIR of 8 mm was selected as the target resolution. After harmonization, all scans met acceptable image quality criteria, while only 13 (39.4%) did before. The harmonization procedure resulted in lower inter-system variability indicators: Mean ± SD COV% (from 16.97 ± 6.03 to 7.86 ± 1.47%), GMRC Inter-Quartile Range (0.040-0.012), and Contrast SD (0.14-0.05). Similar results were obtained with a 6-mm FWHM target EIR. Errors of ± 10% in the DRO activity resulted in differences below 1 mm in the estimated EIR. Conclusion: Harmonizing the EIR of brain PET scans significantly reduced image quality variability while minimally affecting quantitative accuracy. This method can be used prospectively for harmonizing scans to target sharper resolutions and is robust against dose-calibrator errors. Comparable image quality is attainable in brain PET multi-center studies while maintaining quantitative accuracy.
  • dc.description.sponsorship The project leading to this application has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under Grant Agreement No. 115952. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation program and EFPIA.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Shekari M, Verwer EE, Yaqub M, Daamen M, Buckley C, Frisoni GB, et al. Harmonization of brain PET images in multi-center PET studies using Hoffman phantom scan. EJNMMI Phys. 2023 Oct 31;10(1):68. DOI: 10.1186/s40658-023-00588-x
  • dc.identifier.doi http://dx.doi.org/10.1186/s40658-023-00588-x
  • dc.identifier.issn 2197-7364
  • dc.identifier.uri http://hdl.handle.net/10230/60055
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof EJNMMI Phys. 2023 Oct 31;10(1):68
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/115952
  • dc.rights © The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Brain PET
  • dc.subject.keyword Harmonization
  • dc.subject.keyword Neuroimaging
  • dc.subject.keyword Quantification
  • dc.title Harmonization of brain PET images in multi-center PET studies using Hoffman phantom scan
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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