The EU-ADR Web Platform: delivering advanced pharmacovigilance tools

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• dc.contributor.author Oliveira, José Luisca
• dc.contributor.author Lopes, Pedroca
• dc.contributor.author Nunes, Tiagoca
• dc.contributor.author Campos, Davidca
• dc.contributor.author Boyer, Scottca
• dc.contributor.author Ahlberg Helgee, Ernstca
• dc.contributor.author van Mulligen, Erik M.ca
• dc.contributor.author Kors, Jan A.ca
• dc.contributor.author Singh, Baratca
• dc.contributor.author Furlong, Laura I., 1971-ca
• dc.contributor.author Sanz, Ferranca
• dc.contributor.author Bauer-Mehren, Annaca
• dc.contributor.author Carrascosa Baena, María Carmen, 1972-ca
• dc.contributor.author Mestres i López, Jordica
• dc.contributor.author Avillach, Paulca
• dc.contributor.author Diallo, Gayoca
• dc.contributor.author Díaz, Carlosca
• dc.contributor.author van der Lei, Johanca
• dc.date.accessioned 2013-03-06T10:56:09Z
• dc.date.available 2013-03-06T10:56:09Z
• dc.date.issued 2013ca
• dc.description.abstract PURPOSE: Pharmacovigilance methods have advanced greatly during the last decades, making post-market drug assessment an essential drug evaluation component. These methods mainly rely on the use of spontaneous reporting systems and health information databases to collect expertise from huge amounts of real-world reports. The EU-ADR Web Platform was built to further facilitate accessing, monitoring and exploring these data, enabling an in-depth analysis of adverse drug reactions risks./n/nMETHODS: The EU-ADR Web Platform exploits the wealth of data collected within a large-scale European initiative, the EU-ADR project. Millions of electronic health records, provided by national health agencies, are mined for specific drug events, which are correlated with literature, protein and pathway data, resulting in a rich drug-event dataset. Next, advanced distributed computing methods are tailored to coordinate the execution of data-mining and statistical analysis tasks. This permits obtaining a ranked drug-event list, removing spurious entries and highlighting relationships with high risk potential./n/nRESULTS: The EU-ADR Web Platform is an open workspace for the integrated analysis of pharmacovigilance datasets. Using this software, researchers can access a variety of tools provided by distinct partners in a single centralized environment. Besides performing standalone drug-event assessments, they can also control the pipeline for an improved batch analysis of custom datasets. Drug-event pairs can be substantiated and statistically analysed within the platform's innovative working environment./n/nCONCLUSIONS: A pioneering workspace that helps in explaining the biological path of adverse drug reactions was developed within the EU-ADR project consortium. This tool, targeted at the pharmacovigilance community, is available online at https://bioinformatics.ua.pt/euadr/. Copyright © 2012 John Wiley & Sons, Ltd.
• dc.description.sponsorship We wish to thank all the members of the EU-ADR/nproject. This work was supported by the European/nCommission (EU-ADR, ICT-215847), FCT (PTDC//nEIA-CCO/100541/2008) and Instituto de Salud Carlos/nIII FEDER (CP10/00524). The Research Programme/non Biomedical Informatics (GRIB) is a node of the/nSpanish National Institute of Bioinformatics (INB)
• dc.format.mimetype application/pdfca
• dc.identifier.citation Oliveira JL, Lopes P, Nunes T, Campos D, Boyer S, Ahlberg E et al. The EU-ADR Web Platform: delivering advanced pharmacovigilance tools. Pharmacoepidemiol Drug Saf. 2013 May;22(5):459-67. DOI: 10.1002/pds.3375ca
• dc.identifier.doi http://dx.doi.org/10.1002/pds.3375
• dc.identifier.issn 1053-8569ca
• dc.identifier.uri http://hdl.handle.net/10230/20451
• dc.language.iso engca
• dc.publisher John Wiley & Sonsca
• dc.relation.ispartof Pharmacoepidemiology and Drug Safety. 2013 May;22(5):459-67
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/215847
• dc.rights © John Wiley & Sons, Ltd. The definitive version is available at http://onlinelibrary.wiley.com/doi/10.1002/pds.3375/fullca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.keyword Pharmacovigilance
• dc.subject.keyword EU-ADR Web Platform
• dc.subject.keyword Post-market drug assessment
• dc.subject.keyword Drug evaluation
• dc.subject.keyword Drug reactions
• dc.subject.keyword Health information databases
• dc.subject.keyword Datasets
• dc.subject.keyword Reporting systems
• dc.subject.keyword Electronic health records
• dc.subject.other Medicaments -- Efectes secundaris
• dc.subject.other Medicaments -- Anàlisi
• dc.subject.other Medicaments -- Bases de dades
• dc.title The EU-ADR Web Platform: delivering advanced pharmacovigilance toolsca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca