Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data - The European Joint Programme HBM4EU

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• dc.contributor.author Tagne-Fotso, Romuald
• dc.contributor.author Montazeri, Parisa, 1988-
• dc.contributor.author Urquiza, José M.
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Rambaud, Loïc
• dc.date.accessioned 2024-11-20T07:36:10Z
• dc.date.available 2024-11-20T07:36:10Z
• dc.date.issued 2024
• dc.description.abstract Background: Bisphenol A (BPA; or 4,4'-isopropylidenediphenol) is an endocrine disrupting chemical. It was widely used in a variety of plastic-based manufactured products for several years. The European Food Safety Authority (EFSA) recently reduced the Tolerable Daily Intake (TDI) for BPA by 20,000 times due to concerns about immune-toxicity. Objective: We used human biomonitoring (HBM) data to investigate the general level of BPA exposure from 2007 to 2014 of European women aged 18-73 years (n = 4,226) and its determinants. Methods: Fifteen studies from 12 countries (Austria, Belgium, Denmark, France, Germany, Greece, Israel, Luxembourg, Slovenia, Spain, Sweden, and the United Kingdom) were included in the BPA Study protocol developed within the European Joint Programme HBM4EU. Seventy variables related to the BPA exposure were collected through a rigorous post-harmonization process. Linear mixed regression models were used to investigate the determinants of total urine BPA in the combined population. Results: Total BPA was quantified in 85-100 % of women in 14 out of 15 contributing studies. Only the Austrian PBAT study (Western Europe), which had a limit of quantification 2.5 to 25-fold higher than the other studies (LOQ=2.5 µg/L), found total BPA in less than 5 % of the urine samples analyzed. The geometric mean (GM) of total urine BPA ranged from 0.77 to 2.47 µg/L among the contributing studies. The lowest GM of total BPA was observed in France (Western Europe) from the ELFE subset (GM=0.77 µg/L (0.98 µg/g creatinine), n = 1741), and the highest levels were found in Belgium (Western Europe) and Greece (Southern Europe), from DEMOCOPHES (GM=2.47 µg/L (2.26 µg/g creatinine), n = 129) and HELIX-RHEA (GM=2.47 µg/L (2.44 µg/g creatinine), n = 194) subsets, respectively. One hundred percent of women in 14 out of 15 data collections in this study exceeded the health-based human biomonitoring guidance value for the general population (HBM-GVGenPop) of 0.0115 µg total BPA/L urine derived from the updated EFSA's BPA TDI. Variables related to the measurement of total urine BPA and those related to the main socio-demographic characteristics (age, height, weight, education, smoking status) were collected in almost all studies, while several variables related to BPA exposure factors were not gathered in most of the original studies (consumption of beverages contained in plastic bottles, consumption of canned food or beverages, consumption of food in contact with plastic packaging, use of plastic film or plastic containers for food, having a plastic floor covering in the house, use of thermal paper…). No clear determinants of total urine BPA concentrations among European women were found. A broader range of data planned for collection in the original questionnaires of the contributing studies would have resulted in a more thorough investigation of the determinants of BPA exposure in European women. Conclusion: This study highlights the urgent need for action to further reduce exposure to BPA to protect the population, as is already the case in the European Union. The study also underscores the importance of pre-harmonizing HBM design and data for producing comparable data and interpretable results at a European-wide level, and to increase HBM uptake by regulatory agencies.
• dc.description.sponsorship This study was a part of the HBM4EU project receiving funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 733032. Born in Bradford is funded from a variety of sources including A Wellcome Trust infrastructure grant (WT101597MA), a joint grant from the UK Medical Research Council (MRC) and UK Economic and Social Science Research Council (ESRC): MR/N024391/1; The British Heart Foundation (BHF) (CS/16/4/32482); The National Institute for Health and Care Research under its Applied Research Collaboration for Yorkshire and Humber NIHR200166; the European Community’s Seventh Framework Programme (FP7/2007–2013) under grant agreement 308333–the HELIX project. The views expressed in this publication are those of the author(s) and not necessarily those of the National Institute for Health and Care Research or the Department of Health and Social Care. DEMOCOPHES running in 2011–2012 was funded by the 7th European Union program (DG Research – No. 244237-COPHES), with a LIFE+2009 'Policy and governance' (DG Environment – LIFE09/ENV/BE/000410-DEMOCOPHES), with additional co-funding from DEMOCOPHES partners. The Belgian DEMOCOPHES study was co-financed by the Ministers of Environment and Health. It was coordinated by the Federal public service for health, food chain safety and environment (FOD) and followed up by the Belgian Cell Environment and Health including all federal, Flemish, Walloon and Brussels governmental entities working on Health and Environment. The Danish DEMOCOPHES study from 2011 to 2012 was co-financed by the Danish ministries of health, environment and food safety. The contribution of Luxembourg to DEMOCOPHES from 2011 to 2012 was co-financed by Luxembourg Institute of Science and Technology (LIST). The Slovenian DEMOCOPHES study was co-funded by the Slovenian Research Agency program P-0143. DEMOCOPHES in Spain was co-funded by the Spanish Ministry of Agricultures, Food and Environmental and the Instituto de Salud Carlos III (SEG 1251/07 and SEG 1112/10). The German ESB is funded by the Federal Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection. The Israeli IBS study was supported by Research Grant Award No. RGA 902 from the Environment and Health Fund, Jerusalem, Israel. The Austrian PBAT study was partially financed by the former Austrian Federal Ministry of Agriculture, Forestry, Environment and Water Management and by the Environment Agency Austria. Samples were provided from the Austrian Study of Nutritional Status 2012, which was funded by the former Austrian Federal Ministry of Health. The French human biomonitoring program, of which the ELFE cohort was a component, was funded by the French Ministries of Health and the Environment. ELFE benefited from additional funding from the Ministry of Research, Committee on SHS data (CCDSHS) and Ministry of Culture and Communication (Deps), and as part of the RECONAI platform, from National Research Agency funding (ANR-11-EQPX-0038).
• dc.format.mimetype application/pdf
• dc.identifier.citation Tagne-Fotso R, Riou M, Saoudi A, Zeghnoun A, Frederiksen H, Berman T, et al. Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data - The European Joint Programme HBM4EU. Environ Int. 2024 Aug;190:108912. DOI: 10.1016/j.envint.2024.108912
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2024.108912
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/68745
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2024 Aug;190:108912
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733032
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/244237
• dc.rights © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Bisphenol A (BPA)
• dc.subject.keyword Exposure determinants
• dc.subject.keyword HBM4EU
• dc.subject.keyword Human biomonitoring (HBM)
• dc.subject.keyword Human exposure
• dc.subject.keyword Questionnaire harmonization
• dc.subject.keyword Standardized procedures
• dc.subject.keyword Vulnerable population
• dc.title Exposure to bisphenol A in European women from 2007 to 2014 using human biomonitoring data - The European Joint Programme HBM4EU
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion