Risk-stratified strategies in population screening for colorectal cancer
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- dc.contributor.author Lansdorp-Vogelaar, Iris
- dc.contributor.author Meester, Reinier
- dc.contributor.author de Jonge, Lucie
- dc.contributor.author Buron Pust, Andrea
- dc.contributor.author Haug, Ulrike
- dc.contributor.author Senore, Carlo
- dc.date.accessioned 2022-06-14T06:54:30Z
- dc.date.available 2022-06-14T06:54:30Z
- dc.date.issued 2022
- dc.description.abstract Colorectal cancer (CRC) screening has been demonstrated to reduce CRC incidence and mortality. However, besides such benefits, CRC screening is also associated with potential harmful effects. In an ideal world, screening would only be directed to the small proportion of the population that might potentially benefit. Risk-based screening can be seen as a first step towards this ideal world, by redistributing screening resources from low-risk to high-risk individuals. In theory, this should result in scarce resources being used in individuals who benefit most, while intensity of screening is reduced in individuals who benefit less, hence improving the benefit-harm ratio among all invitees. Available strategies that have been proposed for risk-based CRC screening include using information on age, sex, prior screening history, lifestyle and/or genetic information. Implementation of risk-based screening requires careful consideration of reliable risk prediction models, participation with screening and informed decision-making. While it is important to recognise the limitations of current approaches, available evidence suggests that it might be feasible to start planning the introduction of tailored strategies within screening programmes. Implementing risk-based screening based on age, sex and prior screening history alone would already represent a substantial improvement over current uniform screening approaches. We propose that it is time that screening programmes start there and continue striving towards more comprehensive approaches embedding primary prevention as an effective approach to lower risk for everyone.
- dc.format.mimetype application/pdf
- dc.identifier.citation Lansdorp-Vogelaar I, Meester R, de Jonge L, Buron A, Haug U, Senore C. Et al. Risk-stratified strategies in population screening for colorectal càncer. Int J Cancer. 2022 Feb 1; 150(3): 397-405. DOI: 10.1002/ijc.33784
- dc.identifier.doi http://dx.doi.org/10.1002/ijc.33784
- dc.identifier.issn 0020-7136
- dc.identifier.uri http://hdl.handle.net/10230/53484
- dc.language.iso eng
- dc.publisher Wiley
- dc.rights This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, http://creativecommons.org/licenses/by-nc-nd/4.0/, which permits use and distribution in anymedium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made . ©2021 The Authors.International Journal of Cancerpublished by John Wiley & Sons Ltd on behalf of UICC.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
- dc.subject.keyword Colorectal cancer
- dc.subject.keyword Personalised medicine
- dc.subject.keyword Screening
- dc.title Risk-stratified strategies in population screening for colorectal cancer
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion