Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort
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- dc.contributor.author Medrano-Martorell, Santiago
- dc.contributor.author Capellades Font, Jaume
- dc.contributor.author Jiménez Conde, Jordi
- dc.contributor.author González-Ortiz, Sofía
- dc.contributor.author Vilas-González, Marta
- dc.contributor.author Rodríguez-Campello, Ana
- dc.contributor.author Ois Santiago, Angel Javier
- dc.contributor.author Cuadrado-Godia, Elisa
- dc.contributor.author Avellaneda Gómez, Carla
- dc.contributor.author Fernández, Isabel
- dc.contributor.author Merino-Peña, Elisa
- dc.contributor.author Roquer, Jaume
- dc.contributor.author Martí-Fàbregas, Joan
- dc.contributor.author Giralt-Steinhauer, Eva
- dc.date.accessioned 2022-03-31T07:13:46Z
- dc.date.issued 2022
- dc.description.abstract Objectives: The spectrum of distribution of white matter hyperintensities (WMH) may reflect different functional, histopathological, and etiological features. We examined the relationships between cerebrovascular risk factors (CVRF) and different patterns of WMH in MRI using a qualitative visual scale in ischemic stroke (IS) patients. Methods: We assembled clinical data and imaging findings from patients of two independent cohorts with recent IS. MRI scans were evaluated using a modified visual scale from Fazekas, Wahlund, and Van Swieten. WMH distributions were analyzed separately in periventricular (PV-WMH) and deep (D-WMH) white matter, basal ganglia (BG-WMH), and brainstem (B-WMH). Presence of confluence of PV-WMH and D-WMH and anterior-versus-posterior WMH predominance were also evaluated. Statistical analysis was performed with SPSS software. Results: We included 618 patients, with a mean age of 72 years (standard deviation [SD] 11 years). The most frequent WMH pattern was D-WMH (73%). In a multivariable analysis, hypertension was associated with PV-WMH (odds ratio [OR] 1.79, 95% confidence interval [CI] 1.29-2.50, p = 0.001) and BG-WMH (OR 2.13, 95% CI 1.19-3.83, p = 0.012). Diabetes mellitus was significantly related to PV-WMH (OR 1.69, 95% CI 1.24-2.30, p = 0.001), D-WMH (OR 1.46, 95% CI 1.07-1.49, p = 0.017), and confluence patterns of D-WMH and PV-WMH (OR 1.62, 95% CI 1.07-2.47, p = 0.024). Hyperlipidemia was found to be independently related to brainstem distribution (OR 1.70, 95% CI 1.08-2.69, p = 0.022). Conclusions: Different CVRF profiles were significantly related to specific WMH spatial distribution patterns in a large IS cohort.
- dc.format.mimetype application/pdf
- dc.identifier.citation Medrano-Martorell S, Capellades J, Jiménez-Conde J, González-Ortiz S, Vilas-González M, Rodríguez-Campello A, Ois Á, Cuadrado-Godia E, Avellaneda C, Fernández I, Merino-Peña E, Roquer J, Martí-Fàbregas J, Giralt-Steinhauer E. Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort. Eur Radiol. 2022 Jan;32(1):272-80. DOI: 10.1007/s00330-021-08106-2
- dc.identifier.doi http://dx.doi.org/10.1007/s00330-021-08106-2
- dc.identifier.issn 0938-7994
- dc.identifier.uri http://hdl.handle.net/10230/52805
- dc.language.iso eng
- dc.publisher Springer
- dc.relation.ispartof Eur Radiol. 2022 Jan;32(1):272-80
- dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00330-021-08106-2.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Ischemic stroke
- dc.subject.keyword Leukoaraiosis
- dc.subject.keyword Magnetic resonance imaging
- dc.subject.keyword Risk factors
- dc.subject.keyword White matter
- dc.title Risk factors analysis according to regional distribution of white matter hyperintensities in a stroke cohort
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion