Ionizing radiation biomarkers in epidemiological studies - An update

Hall, Janet; Jeggo, Penny A.; West, Catharine; Gomolka, Maria; Quintens, Roel; Badie, Christophe; Laurent, Olivier; Aerts, Ann; Anastasov, Nataša; Azimzadeh, Omid; Azizova, Tamara; Baatout, Sarah; Baselet, Bjorn; Benotmane, Mohammed A.; Blanchardon, Eric; Guéguen, Yann; Haghdoost, Siamak; Harms-Ringhdahl, Mats; Hess, Julia; Kreuzer, Michaela; Laurier, Dominique; Macaeva, Ellina; Manning, Grain; Pernot, Eileen; Ravanat, Jean-Luc; Sabatier, Laure; Tack, Karine; Tapio, Soile; Zitzelsberger, Horst; Cardis, Elisabeth

Ionizing radiation biomarkers in epidemiological studies - An update

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dc.contributor.author Hall, Janetca
dc.contributor.author Jeggo, Penny A.ca
dc.contributor.author West, Catharineca
dc.contributor.author Gomolka, Mariaca
dc.contributor.author Quintens, Roelca
dc.contributor.author Badie, Christopheca
dc.contributor.author Laurent, Olivierca
dc.contributor.author Aerts, Annca
dc.contributor.author Anastasov, Natašaca
dc.contributor.author Azimzadeh, Omidca
dc.contributor.author Azizova, Tamaraca
dc.contributor.author Baatout, Sarahca
dc.contributor.author Baselet, Bjornca
dc.contributor.author Benotmane, Mohammed A.ca
dc.contributor.author Blanchardon, Ericca
dc.contributor.author Guéguen, Yannca
dc.contributor.author Haghdoost, Siamakca
dc.contributor.author Harms-Ringhdahl, Matsca
dc.contributor.author Hess, Juliaca
dc.contributor.author Kreuzer, Michaelaca
dc.contributor.author Laurier, Dominiqueca
dc.contributor.author Macaeva, Ellinaca
dc.contributor.author Manning, Grainca
dc.contributor.author Pernot, Eileenca
dc.contributor.author Ravanat, Jean-Lucca
dc.contributor.author Sabatier, Laureca
dc.contributor.author Tack, Karineca
dc.contributor.author Tapio, Soileca
dc.contributor.author Zitzelsberger, Horstca
dc.contributor.author Cardis, Elisabethca
dc.date.accessioned 2018-06-20T10:10:40Z
dc.date.available 2018-06-20T10:10:40Z
dc.date.issued 2017
dc.description.abstract Recent epidemiology studies highlighted the detrimental health effects of exposure to low dose and low dose rate ionizing radiation (IR): nuclear industry workers studies have shown increased leukaemia and solid tumour risks following cumulative doses of <100mSv and dose rates of <10mGy per year; paediatric patients studies have reported increased leukaemia and brain tumours risks after doses of 30-60mGy from computed tomography scans. Questions arise, however, about the impact of even lower doses and dose rates where classical epidemiological studies have limited power but where subsets within the large cohorts are expected to have an increased risk. Further progress requires integration of biomarkers or bioassays of individual exposure, effects and susceptibility to IR. The European DoReMi (Low Dose Research towards Multidisciplinary Integration) consortium previously reviewed biomarkers for potential use in IR epidemiological studies. Given the increased mechanistic understanding of responses to low dose radiation the current review provides an update covering technical advances and recent studies. A key issue identified is deciding which biomarkers to progress. A roadmap is provided for biomarker development from discovery to implementation and used to summarise the current status of proposed biomarkers for epidemiological studies. Most potential biomarkers remain at the discovery stage and for some there is sufficient evidence that further development is not warranted. One biomarker identified in the final stages of development and as a priority for further research is radiation specific mRNA transcript profiles.
dc.description.sponsorship Research in many of the authors’ laboratories has in-part been supported by the EU FP7 (Grant Number 249689) for the Network of Excellence DoReMi (Low Dose Research towards Multidisciplinary Integration)
dc.format.mimetype application/pdf
dc.identifier.citation Hall J, Jeggo PA, West C, Gomolka M, Quintens R, Badie C et al. Ionizing radiation biomarkers in epidemiological studies - An update. Mutat Res. 2017 Jan - Mar;771:59-84. DOI: 10.1016/j.mrrev.2017.01.001
dc.identifier.doi http://dx.doi.org/10.1016/j.mrrev.2017.01.001
dc.identifier.issn 0027-5107
dc.identifier.uri http://hdl.handle.net/10230/34940
dc.language.iso eng
dc.publisher Elsevierca
dc.relation.ispartof Mutation Research. 2017 Jan - Mar;771:59-84
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/249689
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.other Marcadors bioquímics
dc.subject.other Radiació ionitzant
dc.title Ionizing radiation biomarkers in epidemiological studies - An updateca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/acceptedVersion

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Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)
Articles (Departament de Medicina i Ciències de la Vida)
Documents OpenAIRE (Open Access Infrastructure for Research in Europe)