Long-term cardiac assessment in a sample of adolescent-onset anorexia nervosa

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  • dc.contributor.author Flamarique, Itziar
  • dc.contributor.author Vidal, Barbara
  • dc.contributor.author Plana, Maria Teresa
  • dc.contributor.author Andrés-Perpiñá, Susana
  • dc.contributor.author Gárriz, Miguel
  • dc.contributor.author Sánchez, P.
  • dc.contributor.author Pajuelo, Carolina
  • dc.contributor.author Mont, Lluís
  • dc.contributor.author Castro-Fornieles, Josefina
  • dc.date.accessioned 2022-10-04T06:16:58Z
  • dc.date.available 2022-10-04T06:16:58Z
  • dc.date.issued 2022
  • dc.description.abstract Background: High mortality rates have been reported in patients with anorexia nervosa, mainly due to cardiovascular alterations. The purpose of the present study was to assess cardiac structural and functional abnormalities some 20 years after initial treatment in a sample of adolescent-onset anorexia nervosa (A-AN) and to compare them with matched healthy controls (HC). Methods: A sample of 29 women diagnosed and treated for AN during adolescence (A-AN) were assessed more than 20 years later. A complete cardiac evaluation was carried out including an electrocardiogram (ECG) and a standard 2D echocardiography. Thirty matched HC were also assessed. Results: In the A-AN group, four subjects had a body mass index lower than 18.5 and met full DSM 5 criteria for AN at follow-up (Low-Weight group). They were compared with the rest of the sample (n = 25) who had normalized their weight (Normal-Weight group), though some still showed some eating disorder symptoms. Both groups were compared with the HC group. Subjects in the Low-Weight group presented statistically significant decreases in the left ventricular end-diastolic and left atrium dimensions and left ventricular mass in comparison with the Normal-Weight group and the HC. No other differences in cardiac parameters were found between groups. Conclusions: Echocardiographic and ECG parameters of adults who had presented A-AN twenty years earlier and currently maintained normal weight were similar to those of HC who had never been treated or diagnosed with AN. Adult subjects with A-AN who still had low weight in the long term present certain cardiac abnormalities similar to those seen in short-lasting disease. More studies are needed to confirm these results in a larger sample.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Flamarique I, Vidal B, Plana MT, Andrés-Perpiñá S, Gárriz M, Sánchez P, Pajuelo C, Mont L, Castro-Fornieles J. Long-term cardiac assessment in a sample of adolescent-onset anorexia nervosa. J Eat Disord. 2022 Jan 31;10(1):12. DOI: 10.1186/s40337-022-00533-w
  • dc.identifier.doi http://dx.doi.org/10.1186/s40337-022-00533-w
  • dc.identifier.issn 2050-2974
  • dc.identifier.uri http://hdl.handle.net/10230/54246
  • dc.language.iso eng
  • dc.publisher BioMed Central
  • dc.relation.ispartof J Eat Disord. 2022 Jan 31;10(1):12
  • dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Adolescent
  • dc.subject.keyword Anorexia nervosa
  • dc.subject.keyword Cardiac assessment
  • dc.subject.keyword Long-term follow-up
  • dc.subject.keyword Longitudinal study
  • dc.title Long-term cardiac assessment in a sample of adolescent-onset anorexia nervosa
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion