Relation of prenatal and postnatal PM2.5 exposure with cognitive and motor function among preschool-aged children

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• dc.contributor.author Whitworth, Kristina W.
• dc.contributor.author Rector-Houze, Alison M.
• dc.contributor.author Chen, Wei-Jen
• dc.contributor.author Ibarluzea, Jesús
• dc.contributor.author Swartz, Michael D.
• dc.contributor.author Symanski, Elaine
• dc.contributor.author Iñiguez, Carmen
• dc.contributor.author Lertxundi, Aitana
• dc.contributor.author Valentín, Antònia
• dc.contributor.author González-Safont, Llúcia
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Guxens Junyent, Mònica
• dc.date.accessioned 2024-06-20T07:04:32Z
• dc.date.available 2024-06-20T07:04:32Z
• dc.date.issued 2024
• dc.description.abstract The literature informing susceptible periods of exposure on children's neurodevelopment is limited. We evaluated the impacts of pre- and postnatal fine particulate matter (PM2.5) exposure on children's cognitive and motor function among 1303 mother-child pairs in the Spanish INMA (Environment and Childhood) Study. Random forest models with temporal back extrapolation were used to estimate daily residential PM2.5 exposures that we averaged across 1-week lags during the prenatal period and 4-week lags during the postnatal period. The McCarthy Scales of Children's Abilities (MSCA) were administered around 5 years to assess general cognitive index (GCI) and several subscales (verbal, perceptual-performance, memory, fine motor, gross motor). We applied distributed lag nonlinear models within the Bayesian hierarchical framework to explore periods of susceptibility to PM2.5 on each MSCA outcome. Effect estimates were calculated per 5 μg/m3 increase in PM2.5 and aggregated across adjacent statistically significant lags using cumulative β (βcum) and 95% Credible Intervals (95%CrI). We evaluated interactions between PM2.5 with fetal growth and child sex. We did not observe associations of PM2.5 exposure with lower GCI scores. We found a period of susceptibility to PM2.5 on fine motor scores in gestational weeks 1-9 (βcum = -2.55, 95%CrI = -3.53,-1.56) and on gross motor scores in weeks 7-17 (βcum = -2.27,95%CrI = -3.43,-1.11) though the individual lags for the latter were only borderline statistically significant. Exposure in gestational week 17 was weakly associated with verbal scores (βcum = -0.17, 95%CrI = -0.26,-0.09). In the postnatal period (from age 0.5-1.2 years), we observed a window of susceptibility to PM2.5 on lower perceptual-performance (β = -2.42, 95%CrI = -3.37,-1.46). Unexpected protective associations were observed for several outcomes with exposures in the later postnatal period. We observed no evidence of differences in susceptible periods by fetal growth or child sex. Preschool-aged children's motor function may be particularly susceptible to PM2.5 exposures experienced in utero whereas the first year of life was identified as a period of susceptibility to PM2.5 for children's perceptual-performance.
• dc.description.sponsorship This work was supported by grant R01ES028842 from the National Institutes of Health/National Institute of Environmental Health Sciences, NIH/NIEHS); grants Red INMA G03/176, CB06/02/004; ISCIII-FEDER: PI03/1615, PI04/1509, PI04/1112, PI04/1931, PI04/2018, PI05/1079, PI05/1052, PI06/0867, PI06/1213, PI07/0314, PI09/02311, PI09/02647, PI11/01007, PI11/02591, PI11/02038, PI13/1944, PI13/2032, PI13/02429, PI14/00891, PI14/01687, PI16/1288, PI16/00118, PI17/00663, PI18/00909, PI18/01142, PI18/01237; Miguel Servet-FEDER CP11/00178, CP15/00025, CPII16/00051, CPII18/00018, and CP16/00128 from Instituto de Salud Carlos III, grant 1999SGR 00241from Generalitat de Catalunya-CIRIT, grant FP7-ENV-2011 cod 282957 and HEALTH.2010.2.4.5–1 from the EU Commission, Assistance Award No. R-82811201 from the Health Effects Institute, grant UGP 15-230, UGP-15-244, and UGP-15-249 from Generalitat Valenciana: FISABIO, grant 2005111093 from Alicia Koplowitz Foundation 2017, Department of Health of the Basque Government, grant DFG06/002 from the Provincial Government of Gipuzkoa, and annual agreements with the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain), and Margarita Salas Grant MS21-125 co-funded by European Union- Next Generation EU and Ministerio de Universidades. We also acknowledge support from the Spanish Ministry of Science and Innovation and the State Research Agency through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program. KWW and ES were partially supported by the P30 Environmental Health Sciences Core Center grant P30ES030285 from the NIH/NIEHS and by funding from the NIH/National Institute on Minority Health and Health Disparities (NIMHD) under Award Number P50MD015496.
• dc.format.mimetype application/pdf
• dc.identifier.citation Whitworth KW, Rector-Houze AM, Chen WJ, Ibarluzea J, Swartz M, Symanski E, et al. Relation of prenatal and postnatal PM2.5 exposure with cognitive and motor function among preschool-aged children. Int J Hyg Environ Health. 2024 Mar;256:114317. DOI: 10.1016/j.ijheh.2023.114317
• dc.identifier.doi http://dx.doi.org/10.1016/j.ijheh.2023.114317
• dc.identifier.issn 1438-4639
• dc.identifier.uri http://hdl.handle.net/10230/60532
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Int J Hyg Environ Health. 2024 Mar;256:114317
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
• dc.rights © 2024 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Air pollution
• dc.subject.keyword Cognitive function
• dc.subject.keyword McCarthy scales of Children's abilities
• dc.subject.keyword Motor function
• dc.subject.keyword PM(2.5)
• dc.subject.keyword Susceptible windows
• dc.title Relation of prenatal and postnatal PM2.5 exposure with cognitive and motor function among preschool-aged children
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion