Low phase angle values are associated with malnutrition according to the global leadership initiative on malnutrition criteria in kidney transplant candidates: preliminary assessment of diagnostic accuracy in the FRAILMar study
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- dc.contributor.author Muñoz Redondo, Elena
- dc.contributor.author Morgado Pérez, Andrea
- dc.contributor.author Pérez-Sáez, María José
- dc.contributor.author Faura, Anna
- dc.contributor.author Sánchez-Rodríguez, María Dolores
- dc.contributor.author Tejero Sánchez, Marta
- dc.contributor.author Meza Valderrama, Delky
- dc.contributor.author Muns, Maria Dolors
- dc.contributor.author Pascual, Julio (Pascual Santos)
- dc.contributor.author Marco, Ester
- dc.date.accessioned 2023-06-20T10:29:56Z
- dc.date.available 2023-06-20T10:29:56Z
- dc.date.issued 2023
- dc.description.abstract Malnutrition has a negative impact on patients with chronic diseases and its early identification is a priority. The primary objective of this diagnostic accuracy study was to assess the performance of the phase angle (PhA), a bioimpedance analysis (BIA)-derived parameter, for malnutrition screening using the Global Leadership Initiative for Malnutrition (GLIM) criteria as the reference standard in patients with advanced chronic kidney disease (CKD) waiting for kidney transplantation (KT); criteria associated with low PhA in this population were also analyzed. Sensitivity, specificity, accuracy, positive and negative likelihood ratios, predictive values, and area under the receiver operating characteristic curve were calculated for PhA (index test) and compared with GLIM criteria (reference standard). Of 63 patients (62.9 years old; 76.2% men), 22 (34.9%) had malnutrition. The PhA threshold with the highest accuracy was ≤4.85° (sensitivity 72.7%, specificity 65.9%, and positive and negative likelihood ratios 2.13 and 0.41, respectively). A PhA ≤ 4.85° was associated with a 3.5-fold higher malnutrition risk (OR = 3.53 (CI95% 1.0–12.1)). Considering the GLIM criteria as the reference standard, a PhA ≤ 4.85° showed only fair validity for detecting malnutrition, and thus cannot be recommended as a stand-alone screening tool in this population.
- dc.format.mimetype application/pdf
- dc.identifier.citation Muñoz-Redondo E, Morgado-Pérez A, Pérez-Sáez M, Faura A, Sánchez-Rodríguez D, Tejero-Sánchez M, et al. Low phase angle values are associated with malnutrition according to the global leadership initiative on malnutrition criteria in kidney transplant candidates: preliminary assessment of diagnostic accuracy in the FRAILMar study. Nutrients. 2023 Mar 1;15(5):1084. DOI: 10.3390/nu15051084
- dc.identifier.doi http://dx.doi.org/10.3390/nu15051084
- dc.identifier.issn 2072-6643
- dc.identifier.uri http://hdl.handle.net/10230/57273
- dc.language.iso eng
- dc.publisher MDPI
- dc.relation.ispartof Nutrients. 2023 Mar 1;15(5):1084
- dc.rights © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Phase angle
- dc.subject.keyword Malnutrition
- dc.subject.keyword GLIM
- dc.subject.keyword Muscle mass
- dc.subject.keyword Advanced chronic kidney disease
- dc.subject.keyword Prehabilitation
- dc.title Low phase angle values are associated with malnutrition according to the global leadership initiative on malnutrition criteria in kidney transplant candidates: preliminary assessment of diagnostic accuracy in the FRAILMar study
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion