Mediterranean diet and white blood cell count-A randomized controlled trial

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• dc.contributor.author Hernáez, Álvaro
• dc.contributor.author Lassale, Camille
• dc.contributor.author Castañer, Olga
• dc.contributor.author Estruch, Ramón
• dc.date.accessioned 2022-02-09T07:34:43Z
• dc.date.available 2022-02-09T07:34:43Z
• dc.date.issued 2021
• dc.description.abstract We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × 109 leukocytes/L), mild leukopenia (<4.5 × 109 leukocytes/L), or severe leukopenia (<3.5 × 109 leukocytes/L) in individuals without the condition at baseline (n = 3190, n = 2925, and n = 3190, respectively). We also examined whether MedDiet modified the association between leukocyte count alterations and all-cause mortality. Both MedDiet interventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06% in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54 [0.36-0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groups combined; hazard ratio: 0.25 [0.10-0.60]). High cumulative adherence to a MedDiet was linked to lower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; HRQ4-Q1: 0.29 [0.085-0.99]) and attenuated the association between leukopenia and all-cause mortality (P-interaction = 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations in high cardiovascular risk individuals.
• dc.format.mimetype application/pdf
• dc.identifier.citation Hernáez Á, Lassale C, Castro-Barquero S, Babio N, Ros E, Castañer O et al. Mediterranean diet and white blood cell count-A randomized controlled trial. Foods. 2021;10(6):1268. DOI: 10.3390/foods10061268
• dc.identifier.doi http://dx.doi.org/10.3390/foods10061268
• dc.identifier.issn 2304-8158
• dc.identifier.uri http://hdl.handle.net/10230/52439
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Foods. 2021;10(6):1268
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Mediterranean diet
• dc.subject.keyword Leukocytosis
• dc.subject.keyword Leukopenia
• dc.subject.keyword Prevention
• dc.subject.keyword Randomized controlled trial
• dc.subject.keyword White blood cell count
• dc.title Mediterranean diet and white blood cell count-A randomized controlled trial
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion