Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation
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- dc.contributor.author Gutiérrez Martos, Miriam, 1989-ca
- dc.contributor.author Girard, Benoîtca
- dc.contributor.author Mendonça Netto, Suelica
- dc.contributor.author Perroy, Julieca
- dc.contributor.author Valjent, Emmanuelca
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.contributor.author Martín Sánchez, Miquel, 1971-ca
- dc.date.accessioned 2018-06-05T07:20:47Z
- dc.date.issued 2018
- dc.description.abstract High-palatable and caloric foods are widely overconsumed due to hedonic mechanisms that prevail over caloric necessities leading to overeating and overweight. The nucleus accumbens (NAc) is a key brain area modulating the reinforcing effects of palatable foods and is crucially involved in the development of eating disorders. We describe that prolonged exposure to high-caloric chocolate cafeteria diet leads to overeating and overweight in mice. NAc functionality was altered in these mice, presenting structural plasticity modifications in medium spiny neurons, increased expression of neuroinflammatory factors and activated microglia, and abnormal responses after amphetamine-induced hyperlocomotion. Chronic inactivation of microglia normalized these neurobiological and behavioural alterations exclusively in mice exposed to cafeteria diet. Our data suggest that prolonged exposure to cafeteria diet produces neuroplastic and functional changes in the NAc that can modify feeding behaviour. Microglia activation and neuroinflammation play an important role in the development of these neurobiological alterations.
- dc.description.sponsorship This work was supported by the European Commission, FP7 (#HEALTH‐F2‐2013‐602891) to R.M.; the Spanish Ministerio de Economía y Competitividad‐MINECO (#SAF2014‐59648‐P‐FEDER), the Spanish Instituto de Salud Carlos III, RETICS‐RTA (#RD12/0028/0023‐FEDER) and the Generalitat de Catalunya, AGAUR (#2014‐SGR‐1547) to R.M. The financial support of the Fundació La Marató‐TV3 (#201620‐30) is also acknowledged. We would like to thank the Advance Light Microscopy Unit of the Center for Genomic Regulation for their technical assistance on the acquisition and processing of microscopy images. S. M‐N. was supported by CAPES fellowship of the Brazilian Government (Programa Ciência Sem Fronteiras).
- dc.format.mimetype application/pdf
- dc.identifier.citation Gutiérrez-Martos M, Girard B, Mendonça-Netto S, Perroy J, Valjent E, Maldonado R et al. Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation. Addict Biol. 2018 Mar;23(2):735-49. DOI: 10.1111/adb.12541
- dc.identifier.doi http://dx.doi.org/10.1111/adb.12541
- dc.identifier.issn 1355-6215
- dc.identifier.uri http://hdl.handle.net/10230/34825
- dc.language.iso eng
- dc.publisher Wiley-Blackwellca
- dc.relation.ispartof Addiction Biology. 2018 Mar;23(2):735-49
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/602891
- dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-59648-P
- dc.rights This is the pre-peer reviewed version of the following article: Gutiérrez-Martos M, Girard B, Mendonça-Netto S, Perroy J, Valjent E, Maldonado R et al. Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation. Addict Biol. 2018 Mar; 23(2): 735-749, which has been published in final form at http://dx.doi.org/10.1111/adb.12541. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Neuroinflammation
- dc.subject.keyword Neuronal plasticity
- dc.subject.keyword Nucleus accumbens
- dc.title Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activationca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion