Centrality in the host-pathogen interactome is associated with pathogen fitness during infection

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• dc.contributor.author Crua Asensio, Núriaca
• dc.contributor.author Muñoz Giner, Elisabetca
• dc.contributor.author Sanchez de Groot, Nataliaca
• dc.contributor.author Torrent, Marcca
• dc.date.accessioned 2018-06-26T08:13:10Z
• dc.date.available 2018-06-26T08:13:10Z
• dc.date.issued 2017
• dc.description.abstract To perform their functions proteins must interact with each other, but how these interactions influence bacterial infection remains elusive. Here we demonstrate that connectivity in the host-pathogen interactome is directly related to pathogen fitness during infection. Using Y. pestis as a model organism, we show that the centrality-lethality rule holds for pathogen fitness during infection but only when the host-pathogen interactome is considered. Our results suggest that the importance of pathogen proteins during infection is directly related to their number of interactions with the host. We also show that pathogen proteins causing an extensive rewiring of the host interactome have a higher impact in pathogen fitness during infection. Hence, we conclude that hubs in the host-pathogen interactome should be explored as promising targets for antimicrobial drug design.
• dc.description.sponsorship M.T.B. would like to acknowledge support from the Programa Ramón y Cajal (RYC-2012-09999). This study has been funded by the Ministerio de Economía y Competitividad (SAF2014-56568-R) and a Research Grant 2016 by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) both to M.T.B. N.S.d.G acknowledges support of the Spanish Ministry of Economy and Competitiveness, 'Centro de Excelencia Severo Ochoa 2013-2017' and CERCA Programme from the Generalitat de Catalunya.
• dc.format.mimetype application/pdf
• dc.identifier.citation Crua Asensio N, Muñoz Giner E, de Groot NS, Torrent Burgas M. Centrality in the host-pathogen interactome is associated with pathogen fitness during infection. Nat Commun. 2017 Jan 16;8:14092. DOI: 10.1038/ncomms14092
• dc.identifier.doi http://dx.doi.org/10.1038/ncomms14092
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/34969
• dc.language.iso eng
• dc.publisher Nature Publishing Groupca
• dc.relation.ispartof Nature Communications. 2017 Jan 16;8:14092
• dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-56568-R
• dc.rights © The Author(s) 2017. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Bacterial systems biology
• dc.subject.keyword Pathogens
• dc.subject.keyword Yersinia pestis
• dc.title Centrality in the host-pathogen interactome is associated with pathogen fitness during infectionca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion