Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?
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- dc.contributor.author Rondaan, Christien
- dc.contributor.author Maso, Alessandra
- dc.contributor.author Birlutiu, Rares-Mircea
- dc.contributor.author Fernández Sampedro, Marta
- dc.contributor.author Soriano, Alex
- dc.contributor.author Diaz de Brito, Vicens
- dc.contributor.author Gómez Junyent, Joan
- dc.contributor.author Toro, María Dolores del
- dc.contributor.author Hofstaetter, Jochen Gerhard
- dc.contributor.author Salles, Mauro José
- dc.contributor.author Esteban, Jaime
- dc.contributor.author Wouthuyzen-Bakker, Marjan
- dc.contributor.author ESCMID Study Group on Implant Associated Infections (ESGIAI)
- dc.date.accessioned 2024-05-03T05:53:51Z
- dc.date.available 2024-05-03T05:53:51Z
- dc.date.issued 2023
- dc.description.abstract Objectives: The aim of this study was to investigate the clinical relevance of an isolated positive sonication fluid culture (SFC) in patients who underwent revision surgery of a prosthetic joint. We hypothesized that cases with a positive SFC have a higher rate of infection during follow-up compared with controls with a negative SFC. Methods: This retrospective multicentre observational study was performed within the European Study Group of Implant-Associated Infections. All patients who underwent revision surgery of a prosthetic joint between 2013 and 2019 and had a minimum follow-up of 1 year were included. Patients with positive tissue cultures or synovial fluid cultures were excluded from the study. Results: A total of 95 cases (positive SFC) and 201 controls (negative SFC) were included. Infection during follow-up occurred in 12 of 95 cases (12.6%) versus 14 of 201 controls (7.0%) (p = 0.125). In all, 79.8% of cases were with treated with antibiotics (76/95). Of the non-treated cases, 89% (17/19) had a positive SFC with a low virulent microorganism. When solely analysing patients who were not treated with antibiotics, 16% of the cases (3/19) had an infection during follow-up versus 5% of the controls (9/173) (p = 0.08). Discussion: Although not statistically significant, infections were almost twice as frequent in patients with an isolated positive SFC. These findings require further exploration in larger trials and to conclude about the potential benefit of antibiotic treatment in these cases.
- dc.format.mimetype application/pdf
- dc.identifier.citation Rondaan C, Maso A, Birlutiu RM, Fernandez Sampedro M, Soriano A, Diaz de Brito V, et al. Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?. Clin Microbiol Infect. 2023 Nov;29(11):1431-6. DOI: 10.1016/j.cmi.2023.07.018
- dc.identifier.doi http://dx.doi.org/10.1016/j.cmi.2023.07.018
- dc.identifier.issn 1198-743X
- dc.identifier.uri http://hdl.handle.net/10230/59979
- dc.language.iso eng
- dc.publisher Elsevier
- dc.relation.ispartof Clin Microbiol Infect. 2023 Nov;29(11):1431-6
- dc.rights © 2023 The Authors. Published by Elsevier Ltd on behalf of European Society of Clinical Microbiology and Infectious Diseases. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Culture
- dc.subject.keyword EBJIS
- dc.subject.keyword Periprosthetic joint infection
- dc.subject.keyword Single positive culture
- dc.subject.keyword Sonication
- dc.title Is an isolated positive sonication fluid culture in revision arthroplasties clinically relevant?
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion