Intergenerational and transgenerational epigenetic inheritance in animals
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- dc.contributor.author Perez, Marcos Francisco, 1987-
- dc.contributor.author Lehner, Ben, 1978-
- dc.date.accessioned 2019-07-04T07:00:49Z
- dc.date.available 2019-07-04T07:00:49Z
- dc.date.issued 2019
- dc.description.abstract Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and whether this information changes according to their physiological state and environment. Here, we review recent work on the molecular mechanisms by which 'epigenetic' information is transmitted between generations over different timescales, and the importance of this information for development and physiology.
- dc.description.sponsorship This work was supported by a European Research Council (ERC) consolidator grant (616434), the Spanish Ministry of Economy and Competitiveness (BFU2017-89488-P and SEV-2012-0208), the AXA Research Fund, the Bettencourt Schueller Foundation, Agencia de Gestio d’Ajuts Universitaris i de Recerca (AGAUR; SGR-831), the EMBL-CRG Systems Biology Program and the CERCA Program/Generalitat de Catalunya.
- dc.format.mimetype application/pdf
- dc.identifier.citation Perez MF, Lehner B. Intergenerational and transgenerational epigenetic inheritance in animals. Nat Cell Biol. 2019; 21(2):143-151. DOI 10.1038/s41556-018-0242-9
- dc.identifier.doi http://dx.doi.org/10.1038/s41556-018-0242-9
- dc.identifier.issn 1465-7392
- dc.identifier.uri http://hdl.handle.net/10230/41929
- dc.language.iso eng
- dc.publisher Nature Research
- dc.relation.ispartof Nat Cell Biol. 2019; 21(2):143-151
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/616434
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-89488-P
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV-2012-0208
- dc.rights © Springer Nature Publishing AG Perez MF, Lehner B. Intergenerational and transgenerational epigenetic inheritance in animals. Nat Cell Biol. 2019; 21(2):143-151. DOI 10.1038/s41556-018-0242-9 [http://dx.doi.org/10.1038/s41556-018-0242-9]
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.keyword Epigenetic memory
- dc.subject.keyword Non-coding RNAs
- dc.title Intergenerational and transgenerational epigenetic inheritance in animals
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/acceptedVersion