Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth

Knox, Bethany; Güil Oumrait, Núria; Basagaña Flores, Xavier; Cserbik, Dora; Dadvand, Payam; Foraster Pulido, Maria, 1984-; Galmes, Toni; Gascon Merlos, Mireia, 1984-; Gómez-Roig, María Dolores; Gómez Herrera, Laura C.; Haug, Line Småstuen; Llurba, Elisa; Márquez, Sandra; Rivas, Ioar; Sunyer Deu, Jordi; Thomsen, Cathrine; Zanini, Maria Julia; Bustamante Pineda, Mariona; Vrijheid, Martine

Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth

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dc.contributor.author Knox, Bethany
dc.contributor.author Güil Oumrait, Núria
dc.contributor.author Basagaña Flores, Xavier
dc.contributor.author Cserbik, Dora
dc.contributor.author Dadvand, Payam
dc.contributor.author Foraster Pulido, Maria, 1984-
dc.contributor.author Galmes, Toni
dc.contributor.author Gascon Merlos, Mireia, 1984-
dc.contributor.author Gómez-Roig, María Dolores
dc.contributor.author Gómez Herrera, Laura C.
dc.contributor.author Haug, Line Småstuen
dc.contributor.author Llurba, Elisa
dc.contributor.author Márquez, Sandra
dc.contributor.author Rivas, Ioar
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Thomsen, Cathrine
dc.contributor.author Zanini, Maria Julia
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Vrijheid, Martine
dc.date.accessioned 2024-11-27T07:02:36Z
dc.date.available 2024-11-27T07:02:36Z
dc.date.issued 2024
dc.description.abstract Introduction: The impact of legacy per- and polyfluoroalkyl substances (PFAS) on fetal growth has been well studied, but assessments of next-generation PFAS and PFAS mixtures are sparse and the potential role of fetoplacental hemodynamics has not been studied. We aimed to evaluate associations between prenatal PFAS exposure and fetal growth and fetoplacental hemodynamics. Methods: We included 747 pregnant women from the BiSC birth cohort (Barcelona, Spain (2018-2021)). Twenty-three PFAS were measured at 32 weeks of pregnancy in maternal plasma, of which 13 were present above detectable levels. Fetal growth was measured by ultrasound, as estimated fetal weight at 32 and 37 weeks of gestation, and weight at birth. Doppler ultrasound measurements for uterine (UtA), umbilical (UmA), and middle cerebral artery (MCA) pulsatility indices (PI), as well as the cerebroplacental ratio (CPR - ratio MCA to UmA), were obtained at 32 weeks to assess fetoplacental hemodynamics. We applied linear mixed effects models to assess the association between singular PFAS and longitudinal fetal growth and PI, and Bayesian Weighted Quantile Sum models to evaluate associations between the PFAS mixture and the aforementioned outcomes, controlled for the relevant covariates. Results: Single PFAS and the mixture tended to be associated with reduced fetal growth and CPR PI, but few associations reached statistical significance. Legacy PFAS PFOS, PFHpA, and PFDoDa were associated with statistically significant decreases in fetal weight z-score of 0.13 (95%CI (-0.22, -0.04), 0.06 (-0.10, 0.01), and 0.05 (-0.10, 0.00), respectively, per doubling of concentration. The PFAS mixture was associated with a non-statistically significant 0.09 decrease in birth weight z-score (95%CI -0.22, 0.04) per quartile increase. Conclusion: This study suggests that legacy PFAS may be associated with reduced fetal growth, but associations for next generation PFAS and for the PFAS mixture were less conclusive. Associations between PFAS and fetoplacental hemodynamics warrant further investigation.
dc.description.sponsorship This project was supported by the European Union's Horizon 2020 research and innovation programme under grant agreement no. 874,583 [ATHLETE]. The BiSC cohort was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (785994 – AirNB project) and Health Effects Institute (4959-RFA17-1/18-1 – FRONTIER project) an organization jointly funded by the United States Environmental Protection Agency (EPA) (Assistance Award No. R-82811201) and certain motor vehicle and engine manufacturers. The contents of this article do not necessarily reflect the views of HEI, or its sponsors, nor do they necessarily reflect the views and policies of the EPA or motor vehicle and engine manufacturers. A full list of the funding sources that supported specific parts of the project can be found at https://projectebisc.org/en/funding-sources. Mireia Gascon holds a Miguel Servet fellowship (Grant CP19/00183) funded by Acción Estratégica de Salud - Instituto de Salud Carlos III, co-funded by European Social Fund “Investing in your future”. The publication is part of the fellowship RYC2021-032781-I awarded to Ioar Rivas, funded by the MCIN/AEI/10.13039/501100011033 and the European Union «NextGenerationEU»/PRTR. Nuria Güil-Oumrait is supported by the Secretaria d’Universitats i Recerca de la Generalitat de Catalunya (AGAUR), and Fons Social Europeu (FSE). We acknowledge support from the grant CEX2023-0001290-S funded by MCIN/AEI/ 10.13039/501100011033, and support from the Generalitat de Catalunya through the CERCA Program. We thank all the participants and their families for their generous collaboration. A full list of BiSC researchers can be found at https://projectebisc.org/en/team/.
dc.format.mimetype application/pdf
dc.identifier.citation Knox B, Güil-Oumrait N, Basagaña X, Cserbik D, Dadvand P, Foraster M, et al. Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth. Environ Int. 2024 Nov;193:109090. DOI: 10.1016/j.envint.2024.109090
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2024.109090
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/68835
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environ Int. 2024 Nov;193:109090
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/874583
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/785994
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.keyword Fetal growth
dc.subject.keyword Mixtures
dc.subject.keyword PFAS
dc.subject.keyword Placenta
dc.title Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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