Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis

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  • dc.contributor.author González-Blanco, Leticia
  • dc.contributor.author García-Portilla, María Paz
  • dc.contributor.author Gutiérrez, Miguel
  • dc.contributor.author Mezquida, Gisela
  • dc.contributor.author Cuesta, Manuel J.
  • dc.contributor.author Urbiola, Elena
  • dc.contributor.author Amoretti, Silvia
  • dc.contributor.author Barcones, Fe
  • dc.contributor.author González-Pinto, Ana
  • dc.contributor.author Pina-Camacho, Laura
  • dc.contributor.author Corripio, Iluminada
  • dc.contributor.author Vieta, Eduard
  • dc.contributor.author Baeza, Immaculada
  • dc.contributor.author Toll Privat, Alba
  • dc.contributor.author Sáiz, Pilar A.
  • dc.contributor.author Bobes, Julio
  • dc.contributor.author Bernardo, Miquel
  • dc.contributor.author PEPs Group
  • dc.date.accessioned 2022-07-08T06:39:52Z
  • dc.date.available 2022-07-08T06:39:52Z
  • dc.date.issued 2021
  • dc.description.abstract Objective: There is high prevalence of cigarette smoking in individuals with first-episode psychosis (FEP) prior to psychosis onset. The purpose of the study was to determine the impact of previous tobacco use with or without cannabis on first psychotic experiences in FEP and the impact of this use on age of onset of symptoms, including prodromes. Methods: Retrospective analyses from the naturalistic, longitudinal, multicentre, "Phenotype-Genotype and Environmental Interaction. Application of a Predictive Model in First Psychotic Episodes (PEPs)" Study. The authors analysed sociodemographic/clinical data of 284 FEP patients and 231 matched healthy controls, and evaluated first psychotic experiences of patients using the Symptom Onset in Schizophrenia Inventory. Results: FEP patients had significantly higher prevalence of tobacco, cannabis, and cocaine use than controls. The FEP group with tobacco use only prior to onset (N = 56) had more sleep disturbances (42.9% vs 18.8%, P = 0.003) and lower prevalence of negative symptoms, specifically social withdrawal (33.9% vs 58%, P = 0.007) than FEP with no substance use (N = 70), as well as lower prevalence of ideas of reference (80.4% vs 92.4%, P = 0.015), perceptual abnormalities (46.4% vs 67.4%, P = 0.006), hallucinations (55.4% vs 71.5%, P = 0.029), and disorganised thinking (41.1% vs 61.1%, P = 0.010) than FEP group with previous tobacco and cannabis use (N = 144). FEP patients with cannabis and tobacco use had lower age at first prodromal or psychotic symptom (mean = 23.73 years [SD = 5.09]) versus those with tobacco use only (mean = 26.21 [SD = 4.80]) (P = 0.011). Conclusions: The use of tobacco alone was not related to earlier age of onset of a first psychotic experience, but the clinical profile of FEP patients is different depending on previous tobacco use with or without cannabis.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation González-Blanco L, García-Portilla MP, Gutiérrez M, Mezquida G, Cuesta MJ, Urbiola E, et al. Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis. Schizophr Res. 2021 Oct; 236: 19-28. DOI: 10.1016/j.schres.2021.07.017
  • dc.identifier.doi http://dx.doi.org/10.1016/j.schres.2021.07.017
  • dc.identifier.issn 0920-9964
  • dc.identifier.uri http://hdl.handle.net/10230/53697
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.rights This article is available under the Creative Commons CC-BY-NC-ND license http://creativecommons.org/licenses/by-nc-nd/4.0/ and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword First psychotic symptoms
  • dc.subject.keyword Prodromal symptoms
  • dc.subject.keyword Substance use
  • dc.title Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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