Effect of bariatric surgery on HDL-mediated cholesterol efflux capacity

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• dc.contributor.author Castañer, Olga
• dc.contributor.author Pérez Vega, Karla Alejandra
• dc.contributor.author Álvarez, Sara
• dc.contributor.author Vázquez, Susana
• dc.contributor.author Casajoana, Anna
• dc.contributor.author Blanchart, Gemma
• dc.contributor.author Gaixas, Sònia
• dc.contributor.author Schröder, Helmut, 1958-
• dc.contributor.author Zomeño Fajardo, Maria Dolores
• dc.contributor.author Subirana Cachinero, Isaac
• dc.contributor.author Muñoz Aguayo, Daniel
• dc.contributor.author Fitó Colomer, Montserrat
• dc.contributor.author Benaiges Foix, David
• dc.contributor.author Goday Arno, Alberto
• dc.contributor.author Oliveras, Anna
• dc.date.accessioned 2025-11-14T13:28:31Z
• dc.date.available 2025-11-14T13:28:31Z
• dc.date.issued 2024
• dc.date.updated 2025-11-14T13:28:31Z
• dc.description.abstract Background: Bariatric surgery (BS) is the most effective intervention for severe obesity, leading to sustained weight loss, reduced obesity-related comorbidities, and cardiovascular mortality. Aim: To assess changes in high-density lipoprotein (HDL) functions [cholesterol efflux capacity (CEC) and anti-inflammatory capacity] at different follow-up times in patients with severe obesity undergoing BS. Methods: A prospective observational study within a cohort of consecutively enrolled patients with severe obesity scheduled to undergo BS. In total, 62 participants (77% women), with a mean age of 42.1 years (SD 9.33 years) underwent BS. Regarding the surgical procedure, 27 (43.5%) underwent sleeve gastrectomy and 35 (56.5%) Roux-en-Y gastric bypass. All patients were evaluated preoperatively and at 1, 3, 6, and 12 months after surgery. Results: A decrease in body mass index and an improvement in the systemic lipid profile, indicated by reductions in total cholesterol, low-density lipoprotein cholesterol (LDLc), and remnant cholesterol, and an increase in HDL cholesterol (HDLc) was observed (all p trend < 0.001). Time-series comparisons vs. baseline showed that, in general, anthropometric measures, glycemia, total cholesterol, LDLc, and remnant cholesterol decreased at all follow-ups, whereas HDLc and triglyceride concentrations significantly improved vs. baseline from 6 months, reaching at 12 months the highest HDLc levels (29.6%, p < 0.001) and the lowest circulating triglycerides (-30%, p < 0.001). Although HDL's anti-inflammatory ability worsens after surgery, the HDL-mediated CEC linearly increased after surgery (for both p trend < 0.013). Conclusion: BS improves the lipid profile both quantitatively and qualitatively after 1 year, specifically enhancing HDL-mediated cholesterol efflux capacity, which may contribute to a reduced cardiovascular risk in individuals with severe obesity.
• dc.format.mimetype application/pdf
• dc.identifier.citation Castañer O, Pérez-Vega KA, Álvarez S, Vázquez S, Casajoana A, Blanchart G, Gaixas S, Schröder H, Zomeño MD, Subirana I, Muñoz-Aguayo D, Fitó M, Benaiges D, Goday A, Oliveras A. Effect of bariatric surgery on HDL-mediated cholesterol efflux capacity. Front Cardiovasc Med. 2024 Nov 7:11:1469433. DOI: 10.3389/fcvm.2024.1469433
• dc.identifier.doi http://dx.doi.org/10.3389/fcvm.2024.1469433
• dc.identifier.issn 2297-055X
• dc.identifier.uri http://hdl.handle.net/10230/71883
• dc.language.iso eng
• dc.publisher Frontiers
• dc.relation.ispartof Frontiers in Cardiovascular Medicine. 2024;11:1469433
• dc.rights © 2024 Castañer, Pérez-Vega, Álvarez, Vázquez, Casajoana, Blanchart, Gaixas, Schröder, Zomeño, Subirana, Muñoz-Aguayo, Fitó, Benaiges, Goday and Oliveras. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. http://creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword HDLc
• dc.subject.keyword Cholesterol efflux capacity
• dc.subject.keyword Lipid profile
• dc.subject.keyword Obesity
• dc.subject.keyword Weight loss
• dc.title Effect of bariatric surgery on HDL-mediated cholesterol efflux capacity
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion