Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

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  • dc.contributor.author Dierssen Sotos, Trinidadca
  • dc.contributor.author Palazuelos, Camiloca
  • dc.contributor.author Jiménez-Moleón, José Juanca
  • dc.contributor.author Aragonés, Núriaca
  • dc.contributor.author Altzibar, Jone Mirenca
  • dc.contributor.author Castaño Vinyals, Gemmaca
  • dc.contributor.author Martín Sánchez, Vicenteca
  • dc.contributor.author Gómez-Acebo, Inésca
  • dc.contributor.author Guevara, Marcelaca
  • dc.contributor.author Tardón, Adoninaca
  • dc.contributor.author Pérez-Gómez, Beatrizca
  • dc.contributor.author Amiano, Pilarca
  • dc.contributor.author Moreno, Víctorca
  • dc.contributor.author Molina, Antonio J.ca
  • dc.contributor.author Alonso Molero, Jessicaca
  • dc.contributor.author Moreno-Iribas, Conchica
  • dc.contributor.author Kogevinas, Manolisca
  • dc.contributor.author Pollan, Marinaca
  • dc.contributor.author Llorca, Javierca
  • dc.date.accessioned 2018-10-15T07:57:28Z
  • dc.date.available 2018-10-15T07:57:28Z
  • dc.date.issued 2018
  • dc.description.abstract BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.
  • dc.description.sponsorship This work was partially funded by the “Accion Transversal del Cancer”, approved by the Spanish Ministry Council on the 11th October 2007; The Instituto de Salud Carlos III-FEDER [PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032]; The Fundación Marqués de Valdecilla [API 10/09]; The ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)); The Junta de Castilla y León [LE22A10–2]; The Consejería de Salud of the Junta de Andalucía [2009-S0143]; The Conselleria de Sanitat of the Generalitat Valenciana [AP_061/10]; The Recercaixa [2010ACUP 00310]; The Regional Government of the Basque Country; The Consejería de Sanidad de la Región de Murcia; The European Commission [grants FOOD-CT-2006-036224-HIWATE]; The Spanish Association Against Cancer (AECC) Scientific Foundation; The Catalan Government DURSI [grant 2014SGR647]; The Fundación Caja de Ahorros de Asturias; and the University of Oviedo.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Dierssen-Sotos T, Palazuelos-Calderón C, Jiménez-Moleón JJ, Aragonés N, Altzibar JM, Castaño-Vinyals G et al. Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project. BMC Cancer. 2018 Mar 12;18(1):280. DOI: 10.1186/s12885-018-4182-3
  • dc.identifier.doi http://dx.doi.org/10.1186/s12885-018-4182-3
  • dc.identifier.issn 1471-2407
  • dc.identifier.uri http://hdl.handle.net/10230/35609
  • dc.language.iso eng
  • dc.publisher BioMed Centralca
  • dc.relation.ispartof BMC Cancer. 2018 Mar 12;18(1):280
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/36224
  • dc.rights Copyright © The Author(s). 2018. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/
  • dc.subject.keyword Breast cancer
  • dc.subject.keyword Genetic interactions
  • dc.subject.keyword Reproductive factors
  • dc.subject.other Mama -- Càncer
  • dc.title Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain projectca
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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