Clinical epidemiology of non-alcoholic fatty liver disease in children and adolescents. The LiverKids: Study protocol

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• dc.contributor.author Chacón Valera, Carla
• dc.contributor.author Arteaga, Ingrid
• dc.contributor.author Martínez Escudé, Alba
• dc.contributor.author Ruiz Rojano, Irene
• dc.contributor.author Lamonja Vicente, Noemí
• dc.contributor.author Caballería Rovira, Llorenç
• dc.contributor.author Ribatallada Díez, Anna Maria
• dc.contributor.author Schröder, Helmut, 1958-
• dc.contributor.author Montraveta, Montserrat
• dc.contributor.author Bovo, Maria Victoria
• dc.contributor.author Ginès i Gibert, Pere
• dc.contributor.author Pera, Guillem
• dc.contributor.author Diez Fadrique, Galadriel
• dc.contributor.author Pachón Camacho, Alba
• dc.contributor.author Alonso Pedrol Núria
• dc.contributor.author Graupera, Isabel
• dc.contributor.author Torán Montserrat, Pere
• dc.contributor.author Expósito, Carmen
• dc.date.accessioned 2024-05-31T06:14:32Z
• dc.date.available 2024-05-31T06:14:32Z
• dc.date.issued 2023
• dc.description.abstract Background: Non-alcoholic fatty liver disease (NAFLD) is rapidly increasing alongside overweight and obesity, not only in adults but also in children and adolescents. It is unknown what impact the development of NAFLD in childhood may have in later life. The importance of early detection and treatment lies in its potential for progression to cirrhosis, liver cancer and liver-related death, as well as its associated extrahepatic comorbidities. Vibration-Controlled Transient Elastography (VCTE) with Controlled Attenuation Parameter (CAP) is an effective, non-invasive and safe diagnostic method to estimate the degree of fibrosis and steatosis in the liver, but little is known about its applicability in the paediatric population. Aims: 1) To assess the prevalence of significant liver fibrosis (Liver Stiffness Measurement (LSM) ≥6.5 kPa) using VCTE, and that of non-alcoholic fatty liver disease (≥225 dB/m) using CAP in children and adolescents. 2) To determine the optimal cut-off points of the CAP to achieve maximum concordance with the Magnetic Resonance Imaging (MRI) findings in the diagnosis of mild, moderate and severe NAFLD in children and adolescents. Methods: Cross-sectional population-based study which will include 2,866 subjects aged between 9 and 16 years. Participants will undergo: anamnesis, physical examination, blood extraction, VCTE, MRI and questionnaires on socio-demographic data, personal and family medical history and lifestyle assessment. Applicability and relevance: The study aims to establish the foundations for the use of VCTE in children and adolescents in order to achieve early diagnosis of NAFLD. Moreover, it will serve to understand in further detail the disease and to identify the risk groups of children and adolescents who may be at risk of developing it. Ultimately, this will help determine to which subgroups of the population we need to target resources for prevention and early detection of this entity, as well as possible intervention for its treatment. Trial registration: The LiverKids study is registered on Clinicaltrials.gov (NCT05526274).
• dc.format.mimetype application/pdf
• dc.identifier.citation Chacón C, Arteaga I, Martínez-Escudé A, Ruiz Rojano I, Lamonja-Vicente N, Caballeria L, et al. Clinical epidemiology of non-alcoholic fatty liver disease in children and adolescents. The LiverKids: Study protocol. PLoS One. 2023 Oct 13;18(10):e0286586. DOI: 10.1371/journal.pone.0286586
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0286586
• dc.identifier.issn 1932-6203
• dc.identifier.uri http://hdl.handle.net/10230/60294
• dc.language.iso eng
• dc.publisher Public Library of Science (PLoS)
• dc.relation.ispartof PLoS One. 2023 Oct 13;18(10):e0286586
• dc.rights © 2023 Chacón et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Fibrosis
• dc.subject.keyword Fatty liver
• dc.subject.keyword Magnetic resonance imaging
• dc.subject.keyword Steatosis
• dc.subject.keyword Adolescents
• dc.subject.keyword Liver fibrosis
• dc.subject.keyword Medical risk factors
• dc.subject.keyword Pediatrics
• dc.title Clinical epidemiology of non-alcoholic fatty liver disease in children and adolescents. The LiverKids: Study protocol
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion