Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
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- dc.contributor.author Arnau-Barrés, Isabel
- dc.contributor.author Pascual-Dapena, Ana
- dc.contributor.author López Montesinos, Inmaculada
- dc.contributor.author Gómez-Zorrilla, Silvia
- dc.contributor.author Sorli Redó, M. Luisa
- dc.contributor.author Herrero, Marta
- dc.contributor.author Nogués Solan, Francesc Xavier
- dc.contributor.author Montero, Milagros
- dc.contributor.author Vázquez Ibar, Olga
- dc.contributor.author García-Giralt, Natalia
- dc.contributor.author Miralles Basseda, Ramon
- dc.contributor.author Güerri Fernández, Roberto
- dc.date.accessioned 2022-06-22T06:55:49Z
- dc.date.available 2022-06-22T06:55:49Z
- dc.date.issued 2021
- dc.description.abstract Myocardial involvement during SARS-CoV-2 infection has been reported in many prior publications. We aim to study the prevalence and the clinical implications of acute myocardial injury (MIN) during SARS-CoV-2 infection, particularly in older patients. The method includes a longitudinal observational study with all consecutive adult patients admitted to a COVID-19 unit between March-April 2020. Those aged ≥65 were considered as older adult group. MIN was defined as at least 1 high-sensitive troponin (hs-TnT) concentration above the 99th percentile upper reference limit with different sex-cutoff. Results. Among the 634 patients admitted during the period of observation, 365 (58%) had evidence of MIN, and, of them, 224 (61%) were older adults. Among older adults, MIN was associated with longer time to recovery compared to those without MIN (13 days (IQR 6-21) versus 9 days (IQR 5-17); p < 0.001, respectively. In-hospital mortality was significantly higher in older adults with MIN at admission versus those without it (71 (31%) versus 11 (12%); p < 0.001). In a logistic regression model adjusting by age, sex, severity, and Charlson Comorbidity Index, the OR for in-hospital mortality was 2.1 (95% CI: 1.02-4.42; p = 0.043) among those older adults with MIN at admission. Older adults with acute myocardial injury had greater time to clinical recovery, as well as higher odds of in-hospital mortality.
- dc.format.mimetype application/pdf
- dc.identifier.citation Arnau-Barrés I, Pascual-Dapena A, López-Montesinos I, Gómez-Zorrilla S, Sorlí L, Herrero M, et al. Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults. J Clin Med. 2021 Aug 23;10(16): 3738. DOI: 10.3390/jcm10163738
- dc.identifier.doi http://dx.doi.org/10.3390/jcm10163738
- dc.identifier.issn 2077-0383
- dc.identifier.uri http://hdl.handle.net/10230/53559
- dc.language.iso eng
- dc.publisher MDPI
- dc.rights Copyright © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword SARS-CoV-2
- dc.subject.keyword Myocardial injury
- dc.subject.keyword Older adults
- dc.subject.keyword Prognosis
- dc.title Prevalence and prognostic value of myocardial injury in the initial presentation of SARS-CoV-2 infection among older adults
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion