Long-term stroke recurrence after transient ischemic attack: implications of etiology

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• dc.contributor.author Ois Santiago, Angel Javier
• dc.contributor.author Cuadrado-Godia, Elisa
• dc.contributor.author Giralt-Steinhauer, Eva
• dc.contributor.author Jiménez Conde, Jordi
• dc.contributor.author Soriano Tarraga, Carolina
• dc.contributor.author Rodríguez-Campello, Ana
• dc.contributor.author Avellaneda Gómez, Carla
• dc.contributor.author Cascales Lahoz, Diego
• dc.contributor.author Fernández-Pérez, Isabel
• dc.contributor.author Roquer, Jaume
• dc.date.accessioned 2020-02-18T08:25:29Z
• dc.date.available 2020-02-18T08:25:29Z
• dc.date.issued 2019
• dc.description.abstract Background and purpose: To analyze long-term stroke recurrence (SR) characteristics after transient ischemic attack (TIA) according to initial etiological classification. Methods: A prospective cohort of 706 TIA patients was followed up in a single tertiary stroke center. Endpoint was SR. Etiologic subgroup was determined according to the evidence-based causative classification system. Location of TIA and SR was recorded as right, left, or posterior territory. Disability stroke recurrence (DSR) was defined as modified Rankin Scale (mRS) score >1 or a onepoint increase in those with previous mRS >1 at 3-month follow-up. Results: During a follow-up of 3,493 patient-years (mean follow-up of 58.9±35.9 months), total SR was 125 (17.7%), corresponding to 3.6 recurrences per 100 patient-years. The etiology subgroups with a higher risk of SR were the unclassified (more than one cause) and large-artery atherosclerosis (LAA) categories. Of the SR cases, 88 (70.4%) had the same etiology as the index TIA; again, LAA etiology was the most frequent (83.9%). Notably, cardioaortic embolism was the most frequent cause (62.5%) of SR in the subgroup of 24 patients with undetermined TIA. Overall, SR occurred in the same territory in 74 of 125 patients (59.2%), with significant differences between etiological TIA subgroups (P=0.015). Eighty-two of 125 (65.6%) with SR had DSR, without differences between etiologies (P=0.453). Conclusions: SR occurred mainly with the same etiology and location as initial TIA, although undetermined TIA was associated with a high proportion of cardioaortic embolism SR. More than half of the recurrences caused some disability, regardless of etiology.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ois A, Cuadrado-Godia E, Giralt-Steinhauer E, Jimenez-Conde J, Soriano-Tarraga C, Rodríguez-Campello A et al. Long-term stroke recurrence after transient ischemic attack: implications of etiology. J Stroke. 2019 May;21(2):184-9. DOI: 10.5853/jos.2018.03601
• dc.identifier.doi http://dx.doi.org/10.5853/jos.2018.03601
• dc.identifier.issn 2287-6391
• dc.identifier.uri http://hdl.handle.net/10230/43622
• dc.language.iso eng
• dc.publisher Korean Stroke Society
• dc.relation.ispartof Journal of Stroke. 2019 May;21(2):184-9
• dc.rights Copyright © 2019 Korean Stroke Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
• dc.subject.keyword Ischemic attack
• dc.subject.keyword Transient
• dc.subject.keyword Recurrence
• dc.subject.keyword Stroke
• dc.title Long-term stroke recurrence after transient ischemic attack: implications of etiology
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion