Rapid transcriptional plasticity of duplicated gene clusters enables a clonally reproducing aphid to colonise diverse plant species

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• dc.contributor.author Mathers, Thomas C.ca
• dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-ca
• dc.contributor.author Julca, Ireneca
• dc.contributor.author Loska, Damianca
• dc.contributor.author Hogenhout, Saskia A.ca
• dc.date.accessioned 2018-05-31T07:32:31Z
• dc.date.available 2018-05-31T07:32:31Z
• dc.date.issued 2017
• dc.description.abstract BACKGROUND: The prevailing paradigm of host-parasite evolution is that arms races lead to increasing specialisation via genetic adaptation. Insect herbivores are no exception and the majority have evolved to colonise a small number of closely related host species. Remarkably, the green peach aphid, Myzus persicae, colonises plant species across 40 families and single M. persicae clonal lineages can colonise distantly related plants. This remarkable ability makes M. persicae a highly destructive pest of many important crop species. RESULTS: To investigate the exceptional phenotypic plasticity of M. persicae, we sequenced the M. persicae genome and assessed how one clonal lineage responds to host plant species of different families. We show that genetically identical individuals are able to colonise distantly related host species through the differential regulation of genes belonging to aphid-expanded gene families. Multigene clusters collectively upregulate in single aphids within two days upon host switch. Furthermore, we demonstrate the functional significance of this rapid transcriptional change using RNA interference (RNAi)-mediated knock-down of genes belonging to the cathepsin B gene family. Knock-down of cathepsin B genes reduced aphid fitness, but only on the host that induced upregulation of these genes. CONCLUSIONS: Previous research has focused on the role of genetic adaptation of parasites to their hosts. Here we show that the generalist aphid pest M. persicae is able to colonise diverse host plant species in the absence of genetic specialisation. This is achieved through rapid transcriptional plasticity of genes that have duplicated during aphid evolution.
• dc.format.mimetype application/pdf
• dc.identifier.citation Mathers TC, Chen Y, Kaithakottil G, Legeai F, Mugford ST, Baa-Puyoulet P et al. Rapid transcriptional plasticity of duplicated gene clusters enables a clonally reproducing aphid to colonise diverse plant species. Genome Biol. 2017 Feb 13;18(1):27. DOI: 10.1186/s13059-016-1145-3
• dc.identifier.doi http://dx.doi.org/10.1186/s13059-016-1145-3
• dc.identifier.issn 1474-7596
• dc.identifier.uri http://hdl.handle.net/10230/34757
• dc.language.iso eng
• dc.publisher BioMed Centralca
• dc.relation.ispartof Genome Biology. 2017 Feb 13;18(1):27
• dc.rights © The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Gene duplication
• dc.subject.keyword Genome sequence
• dc.subject.keyword Hemiptera
• dc.subject.keyword Myzus persicae
• dc.subject.keyword Parasite
• dc.subject.keyword Plasticity
• dc.subject.keyword Rna interference (rnai)
• dc.subject.keyword Sap-feeding insects
• dc.subject.keyword Transcriptome
• dc.title Rapid transcriptional plasticity of duplicated gene clusters enables a clonally reproducing aphid to colonise diverse plant speciesca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion