Influence of postoperative complications following esophagectomy for cancer on quality of life. a European multicenter study

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• dc.contributor.author Schuring, Nannet
• dc.contributor.author Jezerskyte, E.
• dc.contributor.author van Berge Henegouwen, Mark I.
• dc.contributor.author Sprangers, M. A. G.
• dc.contributor.author Lagergren, Pernilla
• dc.contributor.author Johar, Asif
• dc.contributor.author Markar, Sheraz R.
• dc.contributor.author Gisbertz, Suzanne S.
• dc.contributor.author LASER study group
• dc.date.accessioned 2023-02-07T07:39:16Z
• dc.date.available 2023-02-07T07:39:16Z
• dc.date.issued 2023
• dc.description.abstract Introduction: postoperative complications following major surgery have been shown to be associated with reduced health-related quality of life (HRQL), and severe complications may have profound negative effects. This study aimed to examine whether long-term HRQL differs with the occurrence and severity of complications in a European multicenter prospective dataset of patients following esophagectomy for cancer. Methods: disease-free patients following esophagectomy for cancer between 2010 and 2016 from the LASER study were included. Patients completed the LASER, EORTC QLQ-C30 and EORTC QLQ-OG25 questionnaires >1 year following treatment. Long-term HRQL was compared between patients with and without postoperative complications, subgroup analysis was performed for severity of complications (no, minor [Clavien-Dindo I-II], severe [Clavien-Dindo ≥ III]), using univariable and multivariable regression. Results: 645 patients were included: 283 patients with no, 207 with minor and 155 with severe complications. Significantly more dyspnea (QLQ-C30) was reported by patients with compared to patients without complications (differenceinmeans6.3). In subgroup analysis, patients with severe complications reported more dyspnea (difference in means 8.3) than patients with no complications. None of the differences were clinically relevant (difference in means ≥ 10 points). LASER-based low mood (OR2.3) was statistically different for minor versus severe complications. Conclusion: comparable HRQL was found in patients with and without postoperative complications following esophagectomy for cancer, after a mean follow-up of 4.4 years. Furthermore, patients with different levels of severity of complications had comparable HRQL. The level of HRQL in esophageal cancer patients are more likely explained by the impact of the complex procedure of the esophagectomy itself.
• dc.format.mimetype application/pdf
• dc.identifier.citation Schuring N, Jezerskyte E, van Berge Henegouwen MI, Sprangers MAG, Lagergren P, Johar A, et al. Influence of postoperative complications following esophagectomy for cancer on quality of life. a European multicenter study. Eur J Surg Oncol. 2023 Jan; 49(1): 97-105. DOI: 10.1016/j.ejso.2022.07.020
• dc.identifier.doi http://dx.doi.org/10.1016/j.ejso.2022.07.020
• dc.identifier.issn 0748-7983
• dc.identifier.uri http://hdl.handle.net/10230/55655
• dc.language.iso eng
• dc.publisher Elsevier
• dc.rights 0748-7983/© 2022 Schuring N, Jezerskyte E, van Berge Henegouwen MI, Sprangers MAG, Lagergren P, Johar A, et al. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Esophageal neoplasms
• dc.subject.keyword Esophagectomy
• dc.subject.keyword Postoperative complications
• dc.subject.keyword Quality of life
• dc.title Influence of postoperative complications following esophagectomy for cancer on quality of life. a European multicenter study
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion