Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study

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  • dc.contributor.author Havet, Anaïs
  • dc.contributor.author Li, Zhen
  • dc.contributor.author Zerimech, Farid
  • dc.contributor.author Sanchez, Margaux
  • dc.contributor.author Siroux, Valérie
  • dc.contributor.author Le Moual, Nicole
  • dc.contributor.author Brunekreef, Bert
  • dc.contributor.author Künzli, Nino
  • dc.contributor.author Jacquemin Leonard, Bénédicte
  • dc.contributor.author Varraso, Raphaëlle
  • dc.contributor.author Matran, Regis
  • dc.contributor.author Nadif, Rachel
  • dc.date.accessioned 2020-06-02T07:28:15Z
  • dc.date.available 2020-06-02T07:28:15Z
  • dc.date.issued 2019
  • dc.description.abstract Background: Evidences that oxidative stress plays a role in the associations between outdoor air pollution and asthma are growing. We aimed to study the role of plasma fluorescent oxidation products levels (FlOPs; an oxidative stress-related biomarker), as potential mediators, in the associations between outdoor air pollution and persistent asthma. Methods: Analyses were conducted in 204 adult asthmatics followed up in the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma). Persistent asthma was defined as having current asthma at EGEA2 (baseline, 2003-2007) and EGEA3 (follow-up, 2011-2013). Exposures to nitrogen dioxide, nitrogen oxides, road traffic, particulate matter with a diameter ≤ 10 μm (PM10) and ≤ 2.5 μm were estimated by ESCAPE models (2009-2010), and ozone (O3) by IFEN models (2004). We used a mediation analysis to assess the mediated effect by FlOPs levels and the interaction between FlOPs levels and air pollution. Results: FlOPs levels increased with PM10 and O3 (adjusted β = 0.04 (95%CI 0.001-0.08), aβ = 0.04 (95%CI 0.009-0.07) per 10 μg/m3, respectively), and the risk of persistent asthma increased with FlOPs levels (aOR = 1.81 (95%CI 1.08-3.02)). The risk of persistent asthma decreased with exposures to NO2, NOx and PM2.5 (aOR ranging from 0.62 to 0.94), and increased with exposures to PM10, O3, O3-summer and road traffic, the greater effect being observed for O3 (aOR = 1.78, 95% CI 0.73-4.37, per 10 μg/m3). Using mediation analysis, we observed a positive total effect (aOR = 2.16, 95%CI 0.70-11.9), a positive direct effect of O3 on persistent asthma (OR = 1.68, 95%CI 0.57-7.25), and a positive indirect effect mediated by FIOPs levels (aOR = 1.28 (95%CI 1.01-2.29)) accounting for 41% of the total effect. Conclusions: Our results add insights on the role of oxidative stress in the association between air pollution and persistent asthma.
  • dc.description.sponsorship This work was supported by the National Hospital program of clinical research [PHRC-national 2012, EvAdA]; ANR-CES-2009; Region Nord Pas-de-Calais; Merck Sharp & Dohme (MSD); the GA2LEN (Global Allergy and Asthma European Network) project; the Fonds AGIR pour les maladies chroniques and ESCAPE [FP7/2007–2011, Grant Nr.211250].
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Havet A, Li Z, Zerimech F, Sanchez M, Siroux V, Le Moual N, Brunekreef B, Künzli N, Jacquemin B, Varraso R, Matran R, Nadif R. Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study. Environ Health. 2019; 18(1):90. DOI: 10.1186/s12940-019-0532-0
  • dc.identifier.doi http://dx.doi.org/10.1186/s12940-019-0532-0
  • dc.identifier.issn 1476-069X
  • dc.identifier.uri http://hdl.handle.net/10230/44863
  • dc.language.iso eng
  • dc.publisher BioMed Central
  • dc.relation.ispartof Environ Health. 2019; 18(1):90
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
  • dc.rights © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Epidemiology
  • dc.subject.keyword Fluorescent oxidation products
  • dc.subject.keyword Mediation analysis
  • dc.subject.keyword Outdoor air pollution
  • dc.subject.keyword Oxidative stress
  • dc.subject.keyword Persistent asthma
  • dc.title Does the oxidative stress play a role in the associations between outdoor air pollution and persistent asthma in adults? Findings from the EGEA study
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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