Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study
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- dc.contributor.author Cano, M.ca
- dc.contributor.author Martínez-Zalacaín, Ignacioca
- dc.contributor.author Bernabéu-Sanz, Ángelaca
- dc.contributor.author Contreras Rodríguez, Oren, 1985-ca
- dc.contributor.author Hernández-Ribas, Rosaca
- dc.contributor.author Via, Estherca
- dc.contributor.author de Arriba-Arnau, Aidaca
- dc.contributor.author Gálvez, V.ca
- dc.contributor.author Urretavizcaya, M.ca
- dc.contributor.author Pujol, Jesúsca
- dc.contributor.author Menchón, José M.ca
- dc.contributor.author Cardoner, Narcísca
- dc.contributor.author Soriano Mas, Carlesca
- dc.date.accessioned 2018-03-07T09:46:35Z
- dc.date.available 2018-03-07T09:46:35Z
- dc.date.issued 2017
- dc.description.abstract Recent research suggests that neuroplastic and neuroinflammatory changes may account for the mode of action of electroconvulsive therapy (ECT), although extant data do not allow for a clear disambiguation between these two hypotheses. Multimodal neuroimaging approaches (for example, combining structural and metabolic information) may help in clarifying this issue. Here we aimed to assess longitudinal changes in (i) regional gray matter (GM) volumes and (ii) hippocampal metabolite concentrations throughout an acute course of bitemporal ECT, as well as (iii) to determine the association between imaging changes and clinical improvement. We assessed 12 patients with treatment-resistant depression (TRD) at four time points (pre-treatment, after the first ECT session, after the ninth ECT session and 15 days after ECT course completion) and 10 healthy participants at two time points, 5 weeks apart. Patients with TRD showed bilateral medial temporal lobe (MTL) and perigenual anterior cingulate cortex volume increases. Left MTL volume increase was associated with (i) a hippocampal N-acetylaspartate concentration decrease, (ii) a hippocampal Glutamate+Glutamine concentration increase and (iii) significant clinical improvement. The observed findings are, in part, compatible with both neuroplastic and neuroinflammatory changes induced by ECT. We postulate that such phenomena may be interrelated, therefore reconciling the neuroplasticity and neuroinflammatory hypotheses of ECT action.
- dc.format.mimetype application/pdf
- dc.identifier.citation Cano M, Martínez-Zalacaín , Bernabéu-Sanz Á, Contreras-Rodríguez O, Hernández-Ribas R, Via E. et al. Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging study. Transl Psychiatry. 2017 Feb 7;7(2):e1023. DOI: 10.1038/tp.2016.267
- dc.identifier.doi http://dx.doi.org/10.1038/tp.2016.267
- dc.identifier.issn 2158-3188
- dc.identifier.uri http://hdl.handle.net/10230/34057
- dc.language.iso eng
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof Translational Psychiatry. 2017 Feb 7;7(2):e1023
- dc.rights Copyright © 2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.subject.other Cervell -- Malalties
- dc.subject.other Depressió psíquica -- Tractament
- dc.title Brain volumetric and metabolic correlates of electroconvulsive therapy for treatment-resistant depression: a longitudinal neuroimaging studyca
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion