Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence

Wickman, Magnus; Lupinek, Christian; Andersson, Niklas; Belgrave, Danielle; Asarnoj, Anna; Benet, Marta; Pinart, Mariona; Wieser, Sandra; García Aymerich, Judith; Baar, Alexandra; Pershagen, Göran; Simpson, Angela; Kull, Inger; Bergström, Anna; Melén, Erik; Hamsten, Carl; Antó i Boqué, Josep Maria; Bousquet, Jean; Custovic, Adnan; Valenta, Rudolf; van Hage, Marianne

Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence

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dc.contributor.author Wickman, Magnusca
dc.contributor.author Lupinek, Christianca
dc.contributor.author Andersson, Niklasca
dc.contributor.author Belgrave, Danielleca
dc.contributor.author Asarnoj, Annaca
dc.contributor.author Benet, Martaca
dc.contributor.author Pinart, Marionaca
dc.contributor.author Wieser, Sandraca
dc.contributor.author García Aymerich, Judithca
dc.contributor.author Baar, Alexandraca
dc.contributor.author Pershagen, Göranca
dc.contributor.author Simpson, Angelaca
dc.contributor.author Kull, Ingerca
dc.contributor.author Bergström, Annaca
dc.contributor.author Melén, Erikca
dc.contributor.author Hamsten, Carlca
dc.contributor.author Antó i Boqué, Josep Mariaca
dc.contributor.author Bousquet, Jeanca
dc.contributor.author Custovic, Adnanca
dc.contributor.author Valenta, Rudolfca
dc.contributor.author van Hage, Marianneca
dc.date.accessioned 2018-03-01T14:49:15Z
dc.date.available 2018-03-01T14:49:15Z
dc.date.issued 2017
dc.description.abstract BACKGROUND: Sensitization in early childhood may precede respiratory allergy in adolescence. METHODS: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16years. Clinically and independent relevant allergen molecules accounting for ≥90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11years (N=248) and the outcome was studied at 11years. FINDINGS: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to ≥3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16years were 100% and 100%, respectively, for IgE reactivity to ≥3 of 5 risk molecules. INTERPRETATIONS: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.
dc.description.sponsorship This study was supported by research grants from the Swedish Asthma and Allergy Foundation, Stockholm County Council (ALF Medicin), Swedish Research Council, the Swedish Heart-Lung Foundation, the Swedish Cancer and Allergy Foundation, the King Gustaf V 80th Birthday Foundation, the Hesselman Foundation, The Konsul Th C Bergh Foundation, the Magnus Bergvall Foundation, Working Life and Welfare, grant F4605 of the Austrian Science Fund (FWF) and by the European Commission's Seventh Framework 29 Program MeDALL under grant agreement No. 261357. Danielle Belgrave is supported through the Medical Research Council Grant MR/M015181/1
dc.format.mimetype application/pdf
dc.identifier.citation Wickman M, Lupinek C, Andersson N, Belgrave D, Asarnoj A, Benet M et al. Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence. EBioMedicine. 2017 Dec;26:91-9. DOI: 10.1016/j.ebiom.2017.11.009
dc.identifier.doi http://dx.doi.org/10.1016/j.ebiom.2017.11.009
dc.identifier.issn 2352-3964
dc.identifier.uri http://hdl.handle.net/10230/34026
dc.language.iso eng
dc.publisher Elsevierca
dc.relation.ispartof EBioMedicine. 2017 Dec;26:91-9
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/261357
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.keyword Asthma
dc.subject.keyword IgE
dc.subject.keyword Rhinitis
dc.subject.keyword Sensitisation
dc.subject.keyword Prediction
dc.title Detection of IgE reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescenceca
dc.type info:eu-repo/semantics/article
dc.type.version info:eu-repo/semantics/publishedVersion

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