Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population

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  • dc.contributor.author Baenas, Isabel
  • dc.contributor.author Castañer Niño, Olga
  • dc.contributor.author Fitó Colomer, Montserrat
  • dc.contributor.author Fernández Aranda, Fernando
  • dc.date.accessioned 2024-10-24T06:55:26Z
  • dc.date.available 2024-10-24T06:55:26Z
  • dc.date.issued 2024
  • dc.description.abstract Objectives: To examine the cross-sectional association between baseline depressive symptoms and the presence of type 2 diabetes (T2D), and its association with glycated hemoglobin (HbA1c) and other metabolic variables, and the prospective association of depressive symptoms and HbA1c after 1 year of follow-up. Methods: n = 6224 Mediterranean older adults with overweight/obesity and metabolic syndrome (48% females, mean age 64.9 ± 4.9 years) were evaluated in the framework of the PREDIMED-Plus study cohort. Depressive symptoms were assessed using the Beck Depression Inventory-II and HbA1c was used to measure metabolic control. Results: The presence of T2D increased the likelihood of higher levels of depressive symptoms (χ2 = 15.84, p = 0.001). Polynomial contrast revealed a positive linear relationship (χ2 = 13.49, p = 0.001), the higher the depressive symptoms levels, the higher the prevalence of T2D. Longitudinal analyses showed that the higher baseline depressive symptoms levels, the higher the likelihood of being within the HbA1c ≥ 7% at 1-year level (Wald-χ2 = 24.06, df = 3, p < .001, for the full adjusted model). Additionally, depressive levels at baseline and duration of T2D predicted higher HbA1c and body mass index, and lower physical activity and adherence to Mediterranean Diet at 1 year of follow-up. Conclusions: This study supports an association between T2D and the severity of depressive symptoms, suggesting a worse metabolic control from mild severity levels in the short-medium term, influenced by lifestyle habits related to diabetes care. Screening for depressive symptoms and a multidisciplinary integrative therapeutic approach should be ensured in patients with T2D.
  • dc.description.sponsorship Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This work was supported by the official Spanish Institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII), through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (six coordinated FIS projects leaded by JS-S and JVi, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332, PI20/01802, PI20/00138, PI20/01532, PI20/00456, PI20/00339, PI20/00557, PI20/00886, PI20/01158); the Especial Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus grant to JS-S; the European Research Council (Advanced Research Grant 2014–2019; agreement #340918) granted to Miguel Ángel Martínez-González; the Recercaixa (number 2013ACUP00194) grant to JS-S; grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018); the PROMETEO/2017/017 grant from the Generalitat Valenciana; the SEMERGEN grant. This study has been also funded by Instituto de Salud Carlos III through the grant CM21/00172 (IB) (co-funded by European Social Fund. ESF investing in your future) and by Sara Borrell fellowship -CD22/00171- (LC-B) and co-founded by the European Union. RG and JS-S are supported by the Catalan Institution for Research and Advanced Studies (ICREA-Academia, 2021-Programme). SGS is a recipient of the Maria Zambrano Fellowship with funding support from the Ministry of Universities and the Recovery, Transformation and Resilience Plan, Spain. The Fellowship is “Funded by the European Union–NextGenerationEU”. CGM receives a predoctoral grant from the University of Rovira i Virgili (2020PMF-PIPF-37). JK was supported by Juan de la Cierva-Incorporación research grant (IJC2019-042420-I) of the Spanish Ministry of Economy, Industry and Competitiveness and European Social Funds. This study has also been funded by European Union’s Horizon 2020 research and innovation program under Grant Agreement No. 847879 (PRIME/H2020, Prevention and Remediation of Insulin Multimorbidity in Europe) and the European Union’s Horizon Europe research and innovation program under grant agreement No 101080219 (eprObes). Additional funding was received by AGAUR-Generalitat de Catalunya (2021-SGR-00824), the PROMETEO/21/2021, and the AICO/2021/347 grants from the Generalitat Valenciana. None of the funding sources took part in the design, collection, analysis, interpretation of the data, or writing the report, or in the decision to submit the manuscript for publication.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Baenas I, Camacho-Barcia L, Granero R, Razquin C, Corella D, Gómez-Martínez C, et al. Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population. J Endocrinol Invest. 2024 Jun;47(6):1405-18. DOI: 10.1007/s40618-023-02278-y
  • dc.identifier.doi http://dx.doi.org/10.1007/s40618-023-02278-y
  • dc.identifier.issn 0391-4097
  • dc.identifier.uri http://hdl.handle.net/10230/68334
  • dc.language.iso eng
  • dc.publisher Springer
  • dc.relation.ispartof J Endocrinol Invest. 2024 Jun;47(6):1405-18
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/847879
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101080219
  • dc.rights © The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/
  • dc.subject.keyword Depressive symptoms
  • dc.subject.keyword HbA1c
  • dc.subject.keyword Metabolic syndrome
  • dc.subject.keyword Severity
  • dc.subject.keyword Type 2 diabetes
  • dc.title Association between type 2 diabetes and depressive symptoms after a 1-year follow-up in an older adult Mediterranean population
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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