Impact of curative treatment on the physical fitness of patients with esophageal cancer: a systematic review and meta-analysis
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- dc.contributor.author Reijneveld, Elja A. E.
- dc.contributor.author Bor, Petra
- dc.contributor.author Dronkers, J.
- dc.contributor.author Argudo Aguirre, Nuria
- dc.contributor.author Ruurda, Jelle P.
- dc.contributor.author Veenhof, Cindy
- dc.date.accessioned 2022-06-03T06:36:46Z
- dc.date.available 2022-06-03T06:36:46Z
- dc.date.issued 2022
- dc.description.abstract Background: Esophageal cancer and curative treatment have a significant impact on the physical fitness of patients. Knowledge about the course of physical fitness during neoadjuvant therapy and esophagectomy is helpful to determine the needs for interventions during and after curative treatment. This study aims to review the current evidence on the impact of curative treatment on the physical fitness of patients with esophageal cancer. Methods: A systematic literature search of PubMed, Embase, Cinahl and the Cochrane Library was conducted up to March 29, 2021. We included observational studies investigating the change of physical fitness (including exercise capacity, muscle strength, physical activity and activities of daily living) from pre-to post-neoadjuvant therapy and/or from pre-to post-esophagectomy. Quality of the studies was assessed and a meta-analysis was performed using standardized mean differences. Results: Twenty-seven articles were included. After neoadjuvant therapy, physical fitness decreased significantly. In the first three months after surgery, physical fitness was also significantly decreased compared to preoperative values. Subgroup analysis showed a restore in exercise capacity three months after surgery in patients who followed an exercise program. Six months after surgery, there was limited evidence that exercise capacity restored to preoperative values. Conclusion: Curative treatment seems to result in a decrease of physical fitness in patients with esophageal cancer, up to three months postoperatively. Six months postoperatively, results were conflicting. In patients who followed a pre- or postoperative exercise program, the postoperative impact of curative treatment seems to be less.
- dc.format.mimetype application/pdf
- dc.identifier.citation Reijneveld EAE, Bor P, Dronkers JJ, Argudo N, Ruurda JP, Veenhof C. Impact of curative treatment on the physical fitness of patients with esophageal cancer: a systematic review and meta-analysis. Eur J Surg Oncol. 2022 Feb; 48(2): 391-402. DOI: 10.1016/j.ejso.2021.08.015
- dc.identifier.doi http://dx.doi.org/10.1016/j.ejso.2021.08.015
- dc.identifier.issn 0748-7983
- dc.identifier.uri http://hdl.handle.net/10230/53381
- dc.language.iso eng
- dc.publisher Elsevier
- dc.rights 0748-7983/© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword Curative treatment
- dc.subject.keyword Esophageal cancer
- dc.subject.keyword Physical fitness
- dc.subject.keyword Physiotherapy
- dc.title Impact of curative treatment on the physical fitness of patients with esophageal cancer: a systematic review and meta-analysis
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion