Sex-dependent psychoneuroendocrine effects of THC and MDMA in an animal model of adolescent drug consumption
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- dc.contributor.author Llorente Berzal, Alvaroca
- dc.contributor.author Puighermanal Puigvert, Emma, 1983-ca
- dc.contributor.author Burokas, Aurelijus, 1982-ca
- dc.contributor.author Ozaita Mintegui, Andrés, 1969-ca
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.contributor.author Viveros, Maria Pazca
- dc.date.accessioned 2015-05-21T10:57:50Z
- dc.date.available 2015-05-21T10:57:50Z
- dc.date.issued 2013ca
- dc.description.abstract Ecstasy is a drug that is usually consumed by young people at the weekends and frequently, in combination with cannabis. In the present study we have investigated the long-term effects of administering increasing doses of delta-9-tetrahydrocannabinol [THC; 2.5, 5, 10 mg/kg; i.p.] from postnatal day (pnd) 28 to 45, alone and/or in conjunction with 3,4-methylenedioxymethamphetamine [MDMA; two daily doses of 10 mg/kg every 5 days; s.c.] from pnd 30 to 45, in both male and female Wistar rats. When tested one day after the end of the pharmacological treatment (pnd 46), MDMA administration induced a reduction in directed exploration in the holeboard test and an increase in open-arm exploration in an elevated plus maze. In the long-term, cognitive functions in the novel object test were seen to be disrupted by THC administration to female but not male rats. In the prepulse inhibition test, MDMA-treated animals showed a decrease in prepulse inhibition at the most intense prepulse studied (80 dB), whereas in combination with THC it induced a similar decrease at 75 dB. THC decreased hippocampal Arc expression in both sexes, while in the frontal cortex this reduction was only evident in females. MDMA induced a reduction in ERK1/2 immunoreactivity in the frontal cortex of male but not female animals, and THC decreased prepro-orexin mRNA levels in the hypothalamus of males, although this effect was prevented when the animals also received MDMA. The results presented indicate that adolescent exposure to THC and/or MDMA induces long-term, sex-dependent psychophysiological alterations and they reveal functional interactions between the two drugs.en
- dc.description.sponsorship Instituto de Salud Carlos III, Redes temáticas de Investigación Cooperativa en salud (ISCIII y FEDER): Red de trastornos adictivos RD06/0001/1013,RD2012/0028/0021 and RD06/001/001; GRUPOS UCM-BSCH (GRUPO UCM 951579); Plan Nacional sobre Drogas en la convocatoria de Orden SAS/1250/2009. ALB has a FPU predoctoral grant from the Ministerio de Ciencia e Innovación.en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Llorente-Berzal A, Puighermanal E, Burokas A, Ozaita A, Maldonado R, Marco EM, Viveros MP. Sex-dependent psychoneuroendocrine effects of THC and MDMA in an animal model of adolescent drug consumption. PLoS ONE. 2013;8(11):e78386. DOI: 10.1371/journal.pone.0078386ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0078386
- dc.identifier.issn 1932-6203ca
- dc.identifier.uri http://hdl.handle.net/10230/23606
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS ONE. 2013;8(11):e78386
- dc.rights © 2013 Llorente-Berzal et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Còrtex cerebralca
- dc.subject.other Hipocamp (Cervell)ca
- dc.subject.other Proteïna tirosina-quinasaca
- dc.title Sex-dependent psychoneuroendocrine effects of THC and MDMA in an animal model of adolescent drug consumptionen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca