Perinatal and childhood factors and risk of breast cancer subtypes in adulthood.

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  • dc.contributor.author Lope, Virginiaca
  • dc.contributor.author Gracia Lavedan, Estherca
  • dc.contributor.author Pumarega Rodríguez, José Antonioca
  • dc.contributor.author Tusquets Trias de Bes, Ignacioca
  • dc.contributor.author Kogevinas, Manolisca
  • dc.contributor.author Castaño Vinyals, Gemmaca
  • dc.contributor.author Pollan, Marinaca
  • dc.date.accessioned 2016-02-16T12:15:46Z
  • dc.date.issued 2016
  • dc.description.abstract BACKGROUND: Accumulated exposure to hormones and growth factors during early life may influence the future risk of breast cancer (BC). This study examines the influence of childhood-related, socio-demographic and anthropometric variables on BC risk, overall and by specific pathologic subtypes. METHODS: This is a case-control study where 1539 histologically-confirmed BC cases (23-85 years) and 1621 population controls, frequency matched by age, were recruited in 10 Spanish provinces. Perinatal and childhood-related characteristics were directly surveyed by trained staff. The association with BC risk, globally and according to menopausal status and pathologic subtypes, was evaluated using logistic and multinomial regression models, adjusting for tumor specific risk factors. RESULTS: Birth characteristics were not related with BC risk. However, women with high socioeconomic level at birth presented a decreased BC risk (OR=0.45; 95% CI=0.29-0.70), while those whose mothers were aged over 39 years at their birth showed an almost significant excess risk of hormone receptor positive tumors (HR+) (OR=1.35; 95% CI=0.99-1.84). Women who were taller than their girl mates before puberty showed increased postmenopausal BC risk (OR=1.26; 95% CI=1.03-1.54) and increased HR+ BC risk (OR=1.26; 95% CI=1.04-1.52). Regarding prepubertal weight, while those women who were thinner than average showed higher postmenopausal BC risk (OR=1.46; 95% CI=1.20-1.78), associated with HR+ tumors (OR=1.34; 95% CI=1.12-1.61) and with triple negative tumors (OR=1.56; 95% CI=1.03-2.35), those who were heavier than average presented lower premenopausal BC risk (OR=0.64; 95% CI=0.46-0.90) and lower risk of epidermal growth factor receptor positive tumors (OR=0.61; 95% CI=0.40-0.93). CONCLUSION: These data reflect the importance of hormones and growth factors in the early stages of life, when the mammary gland is in development and therefore more vulnerable to proliferative stimuli.ca
  • dc.description.sponsorship The authors acknowledge funds provided by the Spanish Ministry of Economy and Competitiveness (Carlos III Institute of Health; PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI08/1770, PI08/0533, PI08/1359, PS09/00773, PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI14/01219 and Rio Hortega CM13/00232), the Catalan Government 2009SGR1489 & 2014SGR756-F, and, by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL, by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571), by the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), by the Recercaixa (2010ACUP 310), by the Regional Government of the Basque Country by European Commission grants FOOD-CT-2006-036224-HIWATE, and by the Spanish Association Against Cancer (AECC) Scientific Foundation.
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Lope V, García-Esquinas E, Pérez-Gómez B, Altzibar JM, Gracia-Lavedan E, Ederra M. et al. Perinatal and childhood factors and risk of breast cancer subtypes in adulthood. Cancer Epidemiol. 2016 Feb;40:22-30. DOI: 10.1016/j.canep.2015.11.004.ca
  • dc.identifier.doi http://dx.doi.org/10.1016/j.canep.2015.11.004
  • dc.identifier.issn 1877-7821
  • dc.identifier.uri http://hdl.handle.net/10230/25830
  • dc.language.iso engca
  • dc.publisher Elsevierca
  • dc.relation.ispartof Cancer Epidemiology. 2016 Feb;40:22-30
  • dc.rights Copyright © 2016 Elsevier B.V. or its licensors or contributors.ca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.subject.other Mama -- Càncerca
  • dc.title Perinatal and childhood factors and risk of breast cancer subtypes in adulthood.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/acceptedVersionca

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