Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila
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- dc.contributor.author Guigó Serra, Rodericca
- dc.contributor.author Blanco, Enriqueca
- dc.contributor.author Pignatelli, Miguelca
- dc.contributor.author Punset, Adriàca
- dc.contributor.author Pérez-Lluch, Sílviaca
- dc.contributor.author Serras Rigalt, Florencica
- dc.contributor.author Corominas Guiu, Montserratca
- dc.date.accessioned 2010-06-10T14:41:25Z
- dc.date.available 2010-06-10T14:41:25Z
- dc.date.issued 2008ca
- dc.description.abstract BACKGROUND: The trithorax group (trxG) and Polycomb group (PcG) proteins are responsible for the maintenance of stable transcriptional patterns of many developmental regulators. They bind to specific regions of DNA and direct the post-translational modifications of histones, playing a role in the dynamics of chromatin structure. RESULTS: We have performed genome-wide expression studies of trx and ash2 mutants in Drosophila melanogaster. Using computational analysis of our microarray data, we have identified 25 clusters of genes potentially regulated by TRX. Most of these clusters consist of genes that encode structural proteins involved in cuticle formation. This organization appears to be a distinctive feature of the regulatory networks of TRX and other chromatin regulators, since we have observed the same arrangement in clusters after experiments performed with ASH2, as well as in experiments performed by others with NURF, dMyc, and ASH1. We have also found many of these clusters to be significantly conserved in D. simulans, D. yakuba, D. pseudoobscura and partially in Anopheles gambiae. CONCLUSION: The analysis of genes governed by chromatin regulators has led to the identification of clusters of functionally related genes conserved in other insect species, suggesting this chromosomal organization is biologically important. Moreover, our results indicate that TRX and other chromatin regulators may act globally on chromatin domains that contain transcriptionally co-regulated genes.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Blanco E, Pignatelli M, Beltran S, Punset A, Pérez-Lluch S, Serras F et al. Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. Genome Biol. 2008; 9(9): 134-134. DOI 10.1186/gb-2008-9-9-r134
- dc.identifier.doi http://dx.doi.org/10.1186/gb-2008-9-9-r134
- dc.identifier.issn 1465-6914
- dc.identifier.uri http://hdl.handle.net/10230/6243
- dc.language.iso engca
- dc.publisher BioMed Centralca
- dc.relation.ispartof Genome Biology 2008; 9(9): r134
- dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/2.0/
- dc.subject.keyword Genome studies
- dc.subject.keyword Evolution
- dc.subject.keyword Model organisms
- dc.subject.keyword Drosofila melanogaster
- dc.subject.other Drosòfila -- Genètica
- dc.subject.other Genètica del desenvolupament
- dc.subject.other Mutació (Biologia)
- dc.title Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophilaca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersion