Increased risk of asthma in overweight children born large for gestational age

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• dc.contributor.author Pinto, Leonardo A.
• dc.contributor.author Guerra, Stefano
• dc.contributor.author Antó i Boqué, Josep Maria
• dc.contributor.author Postma, Dirkje S.
• dc.contributor.author Koppelman, Gerard H.
• dc.contributor.author Jongste, Johan C. de
• dc.contributor.author Gehring, Ulrike
• dc.contributor.author Smit, Henriëtte A.
• dc.contributor.author Wijga, Alet
• dc.date.accessioned 2023-11-21T06:39:46Z
• dc.date.available 2023-11-21T06:39:46Z
• dc.date.issued 2017
• dc.description.abstract Background: Being born large for gestational age (LGA) is a marker of increased growth velocity in fetal life and a risk factor for childhood overweight. Both being born LGA and childhood overweight may influence the development of asthma, although the role of overweight in the association between LGA and childhood asthma is unclear. Importantly, recent studies have suggested that the association between overweight and asthma may be related to non-allergic pathways. If this also applies to the association between LGA and asthma, the association between being born LGA and asthma may be different for atopic and non-atopic children. Objective: We investigated the association of being LGA with the prevalence of asthma at age 8 in atopic and non-atopic children and the role of overweight in this association. Methods: Complete data on asthma, anthropometry and atopy at age of 8 years, and potential confounders were available for 1608 participants of the PIAMA birth cohort. Odds ratios for the association between LGA and asthma in atopic and non-atopic children were estimated by logistic regression analysis adjusting for potential confounders. Overweight was assessed as a potential modifier of the association between LGA and asthma. Results: Being born LGA was not significantly associated with asthma at age of 8 in atopic and non-atopic children. However, overweight at age of 8 years modified the association between asthma at age of 8 and LGA. In non-atopic children, children who were born LGA and were overweight at age of 8 years had a significantly increased odds of asthma compared to non-LGA, non-overweight children (adj OR 7.04; 95% CI 2.2-24). Conclusions: We observed that non-atopic children born LGA, who were overweight by 8 years have an increased risk of asthma. If confirmed, these findings suggest that non-atopic children born LGA may be identified early in life as a high-risk group for asthma.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pinto LA, Guerra S, Anto JM, Postma D, Koppelman GH, Jongste JC de, et al. Increased risk of asthma in overweight children born large for gestational age. Clin Exp Allergy. 2017 Aug;47(8):1050-6. DOI: 10.1111/cea.12961
• dc.identifier.doi http://dx.doi.org/10.1111/cea.12961
• dc.identifier.issn 0954-7894
• dc.identifier.uri http://hdl.handle.net/10230/58320
• dc.language.iso eng
• dc.publisher Wiley
• dc.relation.ispartof Clin Exp Allergy. 2017 Aug;47(8):1050-6
• dc.rights This is the peer reviewed version of the following article: Pinto LA, Guerra S, Anto JM, Postma D, Koppelman GH, de Jongste JC et al. Increased risk of asthma in overweight children born large for gestational age. Clin Exp Allergy. 2017 Aug;47(8):1050-6. DOI: 10.1111/cea.12961, which has been published in final form at http://dx.doi.org/10.1111/cea.12961. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Asthma
• dc.subject.keyword Epidemiology
• dc.subject.keyword Overweight
• dc.subject.keyword Paediatrics
• dc.title Increased risk of asthma in overweight children born large for gestational age
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion