Effect of protocol-related variables and women's characteristics on the cumulative false-positive risk in breast cancer screening

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• dc.contributor.author Román, Rubén
• dc.contributor.author Sala, Maria
• dc.contributor.author Salas, Dolores
• dc.contributor.author Ascunce, Nieves
• dc.contributor.author Zubizarreta, Raquel
• dc.contributor.author Castells, Xavier
• dc.date.accessioned 2025-01-13T08:52:22Z
• dc.date.available 2025-01-13T08:52:22Z
• dc.date.issued 2012
• dc.description.abstract Background: Reducing the false-positive risk in breast cancer screening is important. We examined how the screening-protocol and women's characteristics affect the cumulative false-positive risk. Methods: This is a retrospective cohort study of 1,565,364 women aged 45-69 years who underwent 4,739,498 screening mammograms from 1990 to 2006. Multilevel discrete hazard models were used to estimate the cumulative false-positive risk over 10 sequential mammograms under different risk scenarios. Results: The factors affecting the false-positive risk for any procedure and for invasive procedures were double mammogram reading [odds ratio (OR)=2.06 and 4.44, respectively], two mammographic views (OR=0.77 and 1.56, respectively), digital mammography (OR=0.83 for invasive procedures), premenopausal status (OR=1.31 and 1.22, respectively), use of hormone replacement therapy (OR=1.03 and 0.84, respectively), previous invasive procedures (OR=1.52 and 2.00, respectively), and a familial history of breast cancer (OR=1.18 and 1.21, respectively). The cumulative false-positive risk for women who started screening at age 50-51 was 20.39% [95% confidence interval (CI) 20.02-20.76], ranging from 51.43% to 7.47% in the highest and lowest risk profiles, respectively. The cumulative risk for invasive procedures was 1.76% (95% CI 1.66-1.87), ranging from 12.02% to 1.58%. Conclusions: The cumulative false-positive risk varied widely depending on the factors studied. These findings are relevant to provide women with accurate information and to improve the effectiveness of screening programs.
• dc.format.mimetype application/pdf
• dc.identifier.citation Román R, Sala M, Salas D, Ascunce N, Zubizarreta R, Castells X. Effect of protocol-related variables and women's characteristics on the cumulative false-positive risk in breast cancer screening. Ann Oncol. 2012 Jan;23(1):104-11. DOI: 10.1093/annonc/mdr032
• dc.identifier.doi http://dx.doi.org/10.1093/annonc/mdr032
• dc.identifier.issn 0923-7534
• dc.identifier.uri http://hdl.handle.net/10230/69084
• dc.language.iso eng
• dc.publisher Oxford University Press
• dc.relation.ispartof Ann Oncol. 2012 Jan;23(1):104-11
• dc.rights © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. This is an Open Access article under the CC-BY-NC license (http://creativecommons.org/licenses/by-nc/3.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by-nc/3.0/
• dc.subject.keyword Breast cancer
• dc.subject.keyword False positive
• dc.subject.keyword Invasive procedures
• dc.subject.keyword Risk factors
• dc.subject.keyword Screening
• dc.subject.keyword Variability
• dc.title Effect of protocol-related variables and women's characteristics on the cumulative false-positive risk in breast cancer screening
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion