The LifeCycle Project-EU child cohort network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

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• dc.contributor.author Jaddoe, Vincent W. V.
• dc.contributor.author Sunyer Deu, Jordi
• dc.contributor.author Duijts, Liesbeth
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author LifeCycle Project Group
• dc.date.accessioned 2020-09-14T06:43:12Z
• dc.date.available 2020-09-14T06:43:12Z
• dc.date.issued 2020
• dc.description.abstract Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also provides a novel model for collaborative research in large research infrastructures with individual-level data. The LifeCycle Project will translate results from research using the EU Child Cohort Network into recommendations for targeted prevention strategies to improve health trajectories for current and future generations by optimizing their earliest phases of life.
• dc.description.sponsorship The LifeCycle project received funding from the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 733206 LifeCycle). All study specific acknowledgements and funding are presented in the supplementary materials. This manuscript reflects only the author's view and the Commission is not responsible for any use that may be made of the information it contains
• dc.format.mimetype application/pdf
• dc.identifier.citation Jaddoe VWV, Felix JF, Andersen AN, Charles MA, Chatzi L, Corpeleijn E. et al. The LifeCycle Project-EU child cohort network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents. Eur J Epidemiol. 2020 Jul; 35(7):709-24. DOI: 10.1007/s10654-020-00662-z
• dc.identifier.doi http://dx.doi.org/10.1007/s10654-020-00662-z
• dc.identifier.issn 0393-2990
• dc.identifier.uri http://hdl.handle.net/10230/45280
• dc.language.iso eng
• dc.publisher SpringerOpen
• dc.relation.ispartof European Journal of Epidemiology. 2020 Jul; 35(7):709-24
• dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/733206
• dc.rights This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Birth cohorts;
• dc.subject.keyword Consortium
• dc.subject.keyword Exposome
• dc.subject.keyword Life course
• dc.subject.keyword Non-communicable diseases
• dc.title The LifeCycle Project-EU child cohort network: a federated analysis infrastructure and harmonized data of more than 250,000 children and parents
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion