Variation in predicted COVID-19 risk among lemurs and lorises

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  • dc.contributor.author Melin, Amanda D.
  • dc.contributor.author Orkin, Joseph D.
  • dc.contributor.author Valenzuela, Alejandro
  • dc.contributor.author Gut, Ivo Glynne
  • dc.contributor.author Gut, Marta
  • dc.contributor.author Lizano González, Esther, 1974-
  • dc.contributor.author Marquès i Bonet, Tomàs, 1975-
  • dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
  • dc.contributor.author Juan, David
  • dc.contributor.author Higham, James P.
  • dc.date.accessioned 2021-05-31T11:47:46Z
  • dc.date.issued 2021
  • dc.description.abstract The novel coronavirus SARS-CoV-2, which in humans leads to the disease COVID-19, has caused global disruption and more than 2 million fatalities since it first emerged in late 2019. As we write, infection rates are at their highest point globally and are rising extremely rapidly in some areas due to more infectious variants. The primary target of SARS-CoV-2 is the cellular receptor angiotensin-converting enzyme-2 (ACE2). Recent sequence analyses of the ACE2 gene predict that many nonhuman primates are also likely to be highly susceptible to infection. However, the anticipated risk is not equal across the Order. Furthermore, some taxonomic groups show high ACE2 amino acid conservation, while others exhibit high variability at this locus. As an example of the latter, analyses of strepsirrhine primate ACE2 sequences to date indicate large variation among lemurs and lorises compared to other primate clades despite low sampling effort. Here, we report ACE2 gene and protein sequences for 71 individual strepsirrhines, spanning 51 species and 19 genera. Our study reinforces previous results while finding additional variability in other strepsirrhine species, and suggests several clades of lemurs have high potential susceptibility to SARS-CoV-2 infection. Troublingly, some species, including the rare and endangered aye-aye (Daubentonia madagascariensis), as well as those in the genera Avahi and Propithecus, may be at high risk. Given that lemurs are endemic to Madagascar and among the primates at highest risk of extinction globally, further understanding of the potential threat of COVID-19 to their health should be a conservation priority. All feasible actions should be taken to limit their exposure to SARS-CoV-2.
  • dc.description.sponsorship Funding: CERCA Programme del Departament d'Economia i Coneixement de la Generalitat de Catalunya, Grant/Award Number: GRC 2017SGR 880; Secretaria d'Universitats i Recerca; Spanish Ministry of Science and Innovation‐Instituto de Salud Carlos III; Rockefeller University; Centro de Excelencia Severo Ochoa; Natural Sciences and Engineering Research Council of Canada (NSERC DiscoveryGrant); Generalitat de Catalunya (Departament de Salut, Departament d'Empresa i Coneixement); National Institutes of Health, Grant/Award Number:R35GM130333; CERCA,Grant/Award Numbers: BFU2017‐86471‐P(MINECO/FEDER, UE); European Research Council (ERC)‐European Union's Horizon 2020 research and innovation programme,Grant/Award Number: 864203; Smart Growth Operating Program (2014–2020); MINECO/FEDER, UE, Grant/Award Number: CGL2017‐82654‐P; Unidad de Excelencia María de Maeztu, Grant/Award Number: AEI (CEX2018‐000792‐M); Canada Research Chairs Program; European Regional Development Fund, Grant/Award Numbers: MINECO/FEDER, BIO2015‐71792‐P; Howard Hughes Medical Institute; Obra Social "LaCaixa"; Natural Environment Research Council,Grant/Award Number: NERC NE/T000341/1
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Melin AD, Orkin JD, Janiak MC, Valenzuela A, Kuderna L, Marrone F 3rd et al. Variation in predicted COVID-19 risk among lemurs and lorises. Am J Primatol. 2021 Jun;83(6):e23255. DOI: 10.1002/ajp.23255
  • dc.identifier.doi http://dx.doi.org/10.1002/ajp.23255
  • dc.identifier.issn 0275-2565
  • dc.identifier.uri http://hdl.handle.net/10230/47700
  • dc.language.iso eng
  • dc.publisher Wiley
  • dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/864203
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BIO2015‐71792‐P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017‐86471‐P
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CGL2017‐82654‐P
  • dc.rights This is the peer reviewed version of the following article: Melin AD, Orkin JD, Janiak MC, Valenzuela A, Kuderna L, Marrone F 3rd et al. Variation in predicted COVID-19 risk among lemurs and lorises. Am J Primatol. 2021 Jun;83(6):e23255., which has been published in final form at http://dx.doi.org/10.1002/ajp.23255. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.subject.other COVID-19 (Malaltia)
  • dc.subject.other Lèmurs
  • dc.subject.other Lorísids
  • dc.subject.other Genètica
  • dc.title Variation in predicted COVID-19 risk among lemurs and lorises
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/acceptedVersion

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