The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users

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• dc.contributor.author Batalla, Albertca
• dc.contributor.author Lorenzetti, Valentinaca
• dc.contributor.author Chye ,Yannca
• dc.contributor.author Yucel, Muratca
• dc.contributor.author Soriano Mas, Carlesca
• dc.contributor.author Bhattacharyya, Sagnikca
• dc.contributor.author Torrens, Martaca
• dc.contributor.author Crippa, José A.S.ca
• dc.contributor.author Martín Santos, Rocíoca
• dc.date.accessioned 2018-10-23T07:39:46Z
• dc.date.available 2018-10-23T07:39:46Z
• dc.date.issued 2018
• dc.description.abstract Introduction: Hippocampal neuroanatomy is affected by genetic variations in dopaminergic candidate genes and environmental insults, such as early onset of chronic cannabis exposure. Here, we examine how hippocampal total and subregional volumes are affected by cannabis use and functional polymorphisms of dopamine-relevant genes, including the catechol-O-methyltransferase (COMT), dopamine transporter (DAT1), and the brain-derived neurotrophic factor (BDNF) genes. Material and Methods: We manually traced total hippocampal volumes and automatically segmented hippocampal subregions using high-resolution MRI images, and performed COMT, DAT1, and BDNF genotyping in 59 male Caucasian young adults aged 18-30 years. These included 30 chronic cannabis users with early-onset (regular use at <16 years) and 29 age-, education-, and intelligence-matched controls. Results: Cannabis use and dopaminergic gene polymorphism had both distinct and interactive effects on the hippocampus. We found emerging alterations of hippocampal total and specific subregional volumes in cannabis users relative to controls (i.e., CA1, CA2/3, and CA4), and associations between cannabis use levels and total and specific subregional volumes. Furthermore, total hippocampal volume and the fissure subregion were affected by cannabis×DAT1 polymorphism (i.e., 9/9R and in 10/10R alleles), reflecting high and low levels of dopamine availability. Conclusion: These findings suggest that cannabis exposure alters the normal relationship between DAT1 polymorphism and the anatomy of total and subregional hippocampal volumes, and that specific hippocampal subregions may be particularly affected.
• dc.format.mimetype application/pdf
• dc.identifier.citation Batalla A, Lorenzetti V, Chye Y, Yücel M, Soriano-Mas C, Bhattacharyya S. et al. The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Users. Cannabis Cannabinoid Res. 2018 Feb 1;3(1):1-10. DOI: 10.1089/can.2017.0021
• dc.identifier.doi http://dx.doi.org/10.1089/can.2017.0021
• dc.identifier.issn 2378-8763
• dc.identifier.uri http://hdl.handle.net/10230/35630
• dc.language.iso eng
• dc.publisher Mary Ann Liebertca
• dc.relation.ispartof Cannabis and Cannabinoid Research. 2018 Feb 1;3(1):1-10
• dc.rights Copyright © Albert Batalla et al. 2018; Published by Mary Ann Liebert, Inc. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Brain-derived neurotrophic factor
• dc.subject.keyword Cannabis
• dc.subject.keyword Catechol-O-methyltransferase gene
• dc.subject.keyword Dopamine transporter gene
• dc.subject.keyword Hippocampal subfields
• dc.subject.keyword Hippocampus
• dc.subject.other Hipocamp (Cervell)
• dc.subject.other Cannabis -- Efectes secundaris
• dc.title The Influence of DAT1, COMT, and BDNF Genetic Polymorphisms on Total and Subregional Hippocampal Volumes in Early Onset Heavy Cannabis Usersca
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion