Polymorphisms in ABC transporter genes and concentrations of mercury in newborns - Evidence from two Mediterranean birth cohorts

Llop, Sabrina; Engström, Karin; Ballester Díez, Ferran; Franforte, Elisa; Alhamdow, Ayman; Pisa, Federica; Tratnik, Janja Snoj; Mazej, Datja; Murcia, Mario; Rebagliato, Marisa; Bustamante Pineda, Mariona; Sunyer Deu, Jordi; Sofianou-Katsoulis, Aikaterini; Prasouli, Alexia; Antonopoulou, Eleni; Antoniadou, Ioanna; Nakou, Sheena; Barbone, Fabio; Horvat, Milena; Broberg, Karin

Polymorphisms in ABC transporter genes and concentrations of mercury in newborns - Evidence from two Mediterranean birth cohorts

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dc.contributor.author Llop, Sabrinaca
dc.contributor.author Engström, Karinca
dc.contributor.author Ballester Díez, Ferranca
dc.contributor.author Franforte, Elisaca
dc.contributor.author Alhamdow, Aymanca
dc.contributor.author Pisa, Federicaca
dc.contributor.author Tratnik, Janja Snojca
dc.contributor.author Mazej, Datjaca
dc.contributor.author Murcia, Marioca
dc.contributor.author Rebagliato, Marisaca
dc.contributor.author Bustamante Pineda, Marionaca
dc.contributor.author Sunyer Deu, Jordica
dc.contributor.author Sofianou-Katsoulis, Aikaterinica
dc.contributor.author Prasouli, Alexiaca
dc.contributor.author Antonopoulou, Elenica
dc.contributor.author Antoniadou, Ioannaca
dc.contributor.author Nakou, Sheenaca
dc.contributor.author Barbone, Fabioca
dc.contributor.author Horvat, Milenaca
dc.contributor.author Broberg, Karinca
dc.date.accessioned 2015-05-22T07:45:30Z
dc.date.available 2015-05-22T07:45:30Z
dc.date.issued 2014ca
dc.description.abstract Background: The genetic background may influence methylmercury (MeHg) metabolism and neurotoxicity. ATP binding cassette (ABC) transporters actively transport various xenobiotics across biological membranes. Objective: To investigate the role of ABC polymorphisms as modifiers of prenatal exposure to MeHg. Methods: The study population consisted of participants (n = 1651) in two birth cohorts, one in Italy and Greece (PHIME) and the other in Spain (INMA). Women were recruited during pregnancy in Italy and Spain, and during the perinatal period in Greece. Total mercury concentrations were measured in cord blood samples by atomic absorption spectrometry. Maternal fish intake during pregnancy was determined from questionnaires. Polymorphisms (n = 5) in the ABC genes ABCA1, ABCB1, ABCC1 and ABCC2 were analysed in both cohorts. Results: ABCB1 rs2032582, ABCC1 rs11075290, and ABCC2 rs2273697 modified the associations between maternal fish intake and cord blood mercury concentrations. The overall interaction coefficient between rs2032582 and log2-transformed fish intake was negative for carriers of GT (β = −0.29, 95%CI −0.47, −0.12) and TT (β = −0.49, 95%CI −0.71, −0.26) versus GG, meaning that for a doubling in fish intake of the mothers, children with the rs2032582 GG genotype accumulated 35% more mercury than children with TT. For rs11075290, the interaction coefficient was negative for carriers of TC (β = −0.12, 95%CI −0.33, 0.09), and TT (β = −0.28, 95%CI −0.51, −0.06) versus CC. For rs2273697, the interaction coefficient was positive when combining GA+AA (β = 0.16, 95%CI 0.01, 0.32) versus GG. Conclusion: The ABC transporters appear to play a role in accumulation of MeHg during early development.en
dc.description.sponsorship This study was funded by The European Union 6th and 7th framework projects PHIME NEWGENERIS, the Swedish Research Council for Health, Working Life and Welfare, the Swedish Research Council FORMAS. The INMA study was funded by grants from the Instituto de Salud Carlos III (Red INMA G03/176 and CB06/02/0031), UE (FP7-ENV-2011 DENAMIC cod 282957 and HEALTH.2010.2.4.5-1), Spanish Ministry of Health (FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, 09/02647, 11/02591, 04/1436, 04/2018, 09/02311, 06/0867, 08/1151, 11/02038, CP11/00178), Conselleria de Sanitat Generalitat Valenciana, Generalitat de Catalunya (CIRIT 1999SGR 00241), Fundació La marató de TV3 (090430) and European Union Sixth Framework Project (NEWGENERIS FP6-2003-Food-3-A-016320). National funding for the PHIME project in Slovenia was provided by the programme ARRS P1-0143.en
dc.format.mimetype application/pdfca
dc.identifier.citation Llop S, Engstrom K, Ballester F, Franforte E, Alhamdow A, Pisa F et al. Polymorphisms in ABC transporter genes and concentrations of mercury in newborns - Evidence from two Mediterranean birth cohorts. PLoS ONE. 2014;9(5):e97172. DOI: 10.1371/journal.pone.0097172ca
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0097172
dc.identifier.issn 1932-6203ca
dc.identifier.uri http://hdl.handle.net/10230/23616
dc.language.iso engca
dc.publisher Public Library of Science (PLoS)ca
dc.relation.ispartof PLoS ONE. 2014;9(5):e97172
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/16320ca
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/282957
dc.rights © 2014 Llop et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Fetus -- Creixementca
dc.subject.other Sangca
dc.subject.other Embaràsca
dc.title Polymorphisms in ABC transporter genes and concentrations of mercury in newborns - Evidence from two Mediterranean birth cohortsen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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