Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease

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  • dc.contributor.author Rodríguez-Fernández, Blanca
  • dc.contributor.author Sánchez Benavides, Gonzalo
  • dc.contributor.author Genius, Patricia
  • dc.contributor.author Minguillón, Carolina
  • dc.contributor.author Fauria, Karine
  • dc.contributor.author De Vivo, Immaculata
  • dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
  • dc.contributor.author Molinuevo, José Luis
  • dc.contributor.author Gispert López, Juan Domingo
  • dc.contributor.author Sala Vila, Aleix
  • dc.contributor.author Vilor Tejedor, Natàlia, 1988-
  • dc.contributor.author Crous-Bou, Marta
  • dc.contributor.author ALFA Study
  • dc.date.accessioned 2024-07-16T06:38:24Z
  • dc.date.available 2024-07-16T06:38:24Z
  • dc.date.issued 2024
  • dc.description.abstract Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD. Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested. Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group. Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.
  • dc.description.sponsorship The project leading to these results has received funding from the Alzheimer’s Association (Grant AARG-19–618265). This project has received funding from Instituto de Salud Carlos III (PI19/00119). Additional support has been received from 'la Caixa' Foundation (ID 100010434), under agreement LCF/PR/GN17/50300004, the Alzheimer’s Association and an international anonymous charity foundation through the TriBEKa Imaging Platform project (TriBEKa-17–519007), the Health Department of the Catalan Government (Health Research and Innovation Strategic Plan (PERIS) 2016–2020 grant# SLT002/16/00201), and the Universities and Research Secretariat, Ministry of Business and Knowledge of the Catalan Government under the grant no. 2017-SGR-892. All CRG authors acknowledge the support of the Spanish Ministry of Science, Innovation, and Universities to the EMBL partnership, the Centro de Excelencia Severo Ochoa, and the CERCA Programme / Generalitat de Catalunya. JDG is supported by the Spanish Ministry of Science and Innovation (RYC-2013–13054). GSB has received funding from the Spanish Ministry of Science and Innovation, Spanish Research Agency (PID2020–119556RA-I00). JDG is supported by the Spanish Ministry of Science and Innovation (RYC-2013–13054). NV-T is funded by the Juan de la Cierva Incorporación Programme (IJC2020–043216-I), Ministry of Science and Innovation– Spanish State Research Agency.
  • dc.format.mimetype application/pdf
  • dc.identifier.citation Rodríguez-Fernández B, Sánchez-Benavides G, Genius P, Minguillon C, Fauria K, De Vivo I, et al. Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease. Neurobiol Aging. 2024 Jun 1;141:140-50. DOI: 10.1016/j.neurobiolaging.2024.05.015
  • dc.identifier.doi http://dx.doi.org/10.1016/j.neurobiolaging.2024.05.015
  • dc.identifier.issn 0197-4580
  • dc.identifier.uri http://hdl.handle.net/10230/60762
  • dc.language.iso eng
  • dc.publisher Elsevier
  • dc.relation.ispartof Neurobiol Aging. 2024 Jun 1;141:140-50
  • dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2020–119556RA-I00
  • dc.rights © 2024 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  • dc.rights.accessRights info:eu-repo/semantics/openAccess
  • dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
  • dc.subject.keyword Alzheimer’s disease
  • dc.subject.keyword Biological aging
  • dc.subject.keyword Cognitive performance
  • dc.subject.keyword Sex differences
  • dc.subject.keyword Telomere length
  • dc.title Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease
  • dc.type info:eu-repo/semantics/article
  • dc.type.version info:eu-repo/semantics/publishedVersion

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