Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol

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• dc.contributor.author Martín Sánchez, Ana
• dc.contributor.author González-Pardo, Héctor
• dc.contributor.author Alegre Zurano, Laia
• dc.contributor.author Castro Zavala, Adriana, 1988-
• dc.contributor.author López-Taboada, Isabel
• dc.contributor.author Valverde Granados, Olga
• dc.contributor.author Conejo, Nélida M.
• dc.date.accessioned 2022-10-19T06:33:00Z
• dc.date.issued 2022
• dc.description.abstract Gender is considered as a pivotal determinant of mental health. Indeed, several psychiatric disorders such as anxiety and depression are more common and persistent in women than in men. In the past two decades, impaired brain energy metabolism has been highlighted as a risk factor for the development of these psychiatric disorders. However, comprehensive behavioural and neurobiological studies in brain regions relevant to anxiety and depression symptomatology are scarce. In the present study, we summarize findings describing cannabidiol effects on anxiety and depression in maternally separated female mice as a well-established rodent model of early-life stress associated with many mental disorders. Our results indicate that cannabidiol could prevent anxiolytic- and depressive-related behaviour in early-life stressed female mice. Additionally, maternal separation with early weaning (MSEW) caused long-term changes in brain oxidative metabolism in both nucleus accumbens and amygdalar complex measured by cytochrome c oxidase quantitative histochemistry. However, cannabidiol treatment could not revert brain oxidative metabolism impairment. Moreover, we identified hyperphosphorylation of mTOR and ERK 1/2 proteins in the amygdala but not in the striatum, that could also reflect altered brain intracellular signalling related with to bioenergetic impairment. Altogether, our study supports the hypothesis that MSEW induces profound long-lasting molecular changes in mTOR signalling and brain energy metabolism related to depressive-like and anxiety-like behaviours in female mice, which were partially ameliorated by CBD administration.
• dc.description.sponsorship This work was supported by Ministerio de Economía y Competitividad (grants number PID2019-104077-RB-100 and PSI2017-83038-P), Ministerio de Sanidad, Asuntos Sociales e Igualdad (Retic-ISCIII-RD/16/0017/0010-FEDER) and Plan Nacional Sobre Drogas (#2018/007). The Department of Experimental and Health Sciences (UPF) is a “Unidad de Excelencia María de Maeztu” funded by the AEI (CEX2018-000792-M).
• dc.format.mimetype application/pdf
• dc.identifier.citation Martín-Sánchez A, González-Pardo H, Alegre-Zurano L, Castro-Zavala A, López-Taboada I, Valverde O, Conejo NM. Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol. Prog Neuropsychopharmacol Biol Psychiatry. 2022;115:110508. DOI: 10.1016/j.pnpbp.2021.110508
• dc.identifier.doi http://dx.doi.org/10.1016/j.pnpbp.2021.110508
• dc.identifier.issn 0278-5846
• dc.identifier.uri http://hdl.handle.net/10230/54478
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Prog Neuropsychopharmacol Biol Psychiatry. 2022;115:110508
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-104077-RB-100
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PSI2017-83038-P
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.pnpbp.2021.110508
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Cannabidiol
• dc.subject.keyword Cytochrome c oxidase
• dc.subject.keyword ERK 1/2
• dc.subject.keyword Early life stress
• dc.subject.keyword Maternal separation
• dc.subject.keyword mTOR
• dc.title Early-life stress induces emotional and molecular alterations in female mice that are partially reversed by cannabidiol
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion