Gut-Microbiota-Metabolite Axis in Early Renal Function Decline.

Mostra el registre complet Registre parcial de l'ítem

  • dc.contributor.author Barrios Barrera, Claraca
  • dc.contributor.author Beaumont, Michelleca
  • dc.contributor.author Pallister, Tessca
  • dc.contributor.author Villar García, Juditca
  • dc.contributor.author Goodrich, Julia K.ca
  • dc.contributor.author Clark, Andrewca
  • dc.contributor.author Pascual Santos, Julioca
  • dc.contributor.author Ley, Ruth E.ca
  • dc.contributor.author Spector, Tim D.ca
  • dc.contributor.author Bell, Jordana T.ca
  • dc.contributor.author Menni, Cristinaca
  • dc.date.accessioned 2015-10-05T07:52:29Z
  • dc.date.available 2015-10-05T07:52:29Z
  • dc.date.issued 2015
  • dc.description.abstract INTRODUCTION: Several circulating metabolites derived from bacterial protein fermentation have been found to be inversely associated with renal function but the timing and disease severity is unclear. The aim of this study is to explore the relationship between indoxyl-sulfate, p-cresyl-sulfate, henylacetylglutamine and gut-microbial profiles in early renal function decline. RESULTS: Indoxyl-sulfate (Beta(SE) = -2.74(0.24); P = 8.8x10-29), p-cresyl-sulfate (-1.99(0.24), P = 4.6x10-16), and phenylacetylglutamine(-2.73 (0.25), P = 1.2x10-25) were inversely associated with eGFR in a large population base cohort (TwinsUK, n = 4439) with minimal renal function decline. In a sub-sample of 855 individuals, we analysed metabolite associations with 16S gut microbiome profiles (909 profiles, QIIME 1.7.0). Three Operational Taxonomic Units (OTUs) were significantly associated with indoxyl-sulfate and 52 with phenylacetylglutamine after multiple testing; while one OTU was nominally associated with p-cresyl sulfate. All 56 microbial members belong to the order Clostridiales and are represented by anaerobic Gram-positive families Christensenellaceae, Ruminococcaceae and Lachnospiraceae. Within these, three microbes were also associated with eGFR. CONCLUSIONS: Our data suggest that indoxyl-sulfate, p-cresyl-sulfate and phenylacetylglutamine are early markers of renal function decline. Changes in the intestinal flora associated with these metabolites are detectable in early kidney disease. Future efforts should dissect this relationship to improve early diagnostics and therapeutics strategies.ca
  • dc.description.sponsorship TwinsUK was funded by the Wellcome Trust; European Community’s Seventh Framework Programme (FP7/2007-2013). The study also receives support from the National Institute for Health Research (NIHR) Clinical Research Facility at Guy’s & St Thomas’ NHS Foundation Trust and NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust, the King's College London, the Cornell Centre for Comparative Population Genomics. Tim Spector is the holder of an ERC Advanced Principal Investigator award. Clara Barrios is supported by a grant from the Spanish Society of Nephrology
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Barrios C, Beaumont M, Pallister T, Villar J, Goodrich JK, Clark A. et al. Gut-Microbiota-Metabolite Axis in Early Renal Function Decline. PLoS One. 2015 Aug 4;10(8):e0134311. doi: 10.1371/journal.pone.0134311.ca
  • dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0134311
  • dc.identifier.issn 1932-6203
  • dc.identifier.uri http://hdl.handle.net/10230/24802
  • dc.language.iso engca
  • dc.publisher Public Library of Scienceca
  • dc.relation.ispartof PLoS One. 2015 Aug 4;10(8):e0134311
  • dc.rights : © 2015 Barrios et al. This is an open access article distributed under the terms of thehttp://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are/ncreditedca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
  • dc.subject.other Aparell urinari -- Fisiologiaca
  • dc.title Gut-Microbiota-Metabolite Axis in Early Renal Function Decline.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

Col·leccions

Articles (Hospital del Mar Research Institute)